Multi-sensor management and control technology generally constructs a reasonable objective function to solve the optimal control command set to control a limited number of sensors to obtain higher quality measurement information, thus obtaining better target tracking performance. In the process of multi-sensor information fusion, there is not only the problem of information redundancy but also obvious time delay. A sensor fusion algorithm combined with global optimization algorithm is innovatively proposed. According to the key frames saved in the previous steps, feature points in local maps, sensor information, and loop information, a global optimization algorithm based on graph optimization model is constructed to optimize the position and pose of intelligent hardware system and the position of spatial feature points. Moreover, this work studies and experiments on multi-sensor fusion simultaneous localization and mapping (SLAM) comprehensively and systematically, and the experimental results show that the algorithm proposed in this work is superior to common open-source SLAM algorithm in positioning accuracy and mapping effect under special circumstances. Therefore, the method proposed in this work can be applied to intelligent driving of vehicles, vision-assisted movement of robots and intelligent control of unmanned aerial vehicles, thus effectively improving the hardware control accuracy of intelligent systems.