Top-down estimates of fossil fuel CO 2 (FFCO 2 ) emissions are crucial for tracking emissions and evaluating mitigation strategies. However, their practical application is hindered by limited data coverage and overreliance on NOx-to-CO 2 emission ratios from emission inventories. We developed the Machine Learning-Driven Mapping Satellite-based XCO 2en (ML-MSXE) model using the columnaveraged dry-air mole fraction of CO 2 enhancement (XCO 2en ) derived from OCO-2 and OCO-3 measurements to reconstruct the XCO 2en distribution for monitoring FFCO 2 emissions. Compared to the previous Machine Learning-Driven Deriving XCO 2en from Mapped XCO 2 (ML-DXEMX) model, ML-MSXE enhances the utilization of TROPOMI NO 2 measurements, increasing their relative contribution from 4.3 to 21.7%, thereby improving XCO 2en reconstruction accuracy and enhancing the ability to track emissions. Despite the COVID-19 lockdown, XCO 2en levels in China rose from 1.33 ± 1.06 in 2019 to 1.39 ± 1.01 ppm in 2021. In February 2020, while the national average rate of XCO 2en decline (16.3%) aligned with the reduction in FFCO 2 emissions estimated by inventories, XCO 2en further revealed varying rates of decline between cities. Furthermore, the spatial distribution of XCO 2en identified hotspots where FFCO 2 emissions might be underestimated by inventories. This study presents a space-based approach for monitoring FFCO 2 emissions, offering valuable insights for assessing carbon neutrality progress and informing policy.