Multi-site benchmarking of clinical 13C RF coils at 3T

Sánchez‐Heredia, Juan D.; Olin, Rie B.; Laustsen, Christoffer; Hansen, Adam E.; Hanson, Lars G.; Ardenkjær-Larsen, Jan Henrik

doi:10.1016/j.jmr.2020.106798

Cited by 10 publications

(31 citation statements)

References 36 publications

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“…The steps for QC [46], including sterilizing the polarizer components and verifying the sample pH, temperature, volume, concentration, and polarization, have been optimized to decrease the time to injection from 88 (74 114) (mean (min max)) [43] to 58 (49 83) s [46] in patients with glioma. Several 13 C RF multichannel coils have been developed to obtain 13 C signals with distinct advantages [47,48]. The choice of use could depend on the regions of interest, head size, and the acquisition methods (e.g., parallel imaging).…”

Section: Considerations In Translating Dynamic Hyperpolarized 13 C Metabolic Imaging To Clinical Brain Studiesmentioning

confidence: 99%

Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging

Vigneron

2021

Eur J Nucl Med Mol Imaging

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The ability of hyperpolarized carbon-13 MR metabolic imaging to acquire dynamic metabolic information in real time is crucial to gain mechanistic insights into metabolic pathways, which are complementary to anatomic and other functional imaging methods. This review presents the advantages of this emerging functional imaging technology, describes considerations in clinical translations, and summarizes current human brain applications. Despite rapid development in methodologies, significant technological and physiological related challenges continue to impede broader clinical translation.

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Section: Considerations In Translating Dynamic Hyperpolarized 13 C Metabolic Imaging To Clinical Brain Studiesmentioning

confidence: 99%

Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging

Vigneron

2021

Eur J Nucl Med Mol Imaging

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“…In addition to pyruvate, other hyperpolarized 13 C substrates have been investigated from [1,[4][5][6][7][8][9][10][11][12][13] C 2 ]fumarate to [1,[4][5][6][7][8][9][10][11][12][13] C 2 ]malate. Moreover, 13 C-bicarbonate and 13 Ccarbon dioxide have been investigated to measure extracellular pH.…”

Section: Hyperpolarized 13 C Magnetic Resonancementioning

confidence: 99%

“…All elements of the array are separately connected to receiver channels whose outputs are optimally combined with a phase correction, which is dependent on the point in space from which the signal originates. Figure 2 shows an example of SNR images obtained with different geometrical coils for the same cylindrical phantom [7]. Volume (birdcage and Helmholtz), phased array (8, 14, and 16 channels), and surface coils provide very different SNR distributions.…”

Section: Coil Classification: Surface Volume and Phased-array Coilsmentioning

confidence: 99%

“…Different magnetic field mapping methods, divided into electromagnetic bench tests and MRI techniques, can be used to estimate the coil efficiency at a fixed point, according to Equation (7). We tested the following four different methods: three methods for efficiency measurements using "probe techniques" (perturbing loop, perturbing sphere, and pick-up coil), and one NMR technique-based method.…”

Section: Efficiency Measurementmentioning

confidence: 99%

“…The choice of the most suitable coil for a given application is a necessary constraint. Recently, a quality assurance imaging protocol for 13 C coils based on MR spectroscopic imaging was described in the literature [7], in which different coil setups were tested and compared.…”

Section: Introductionmentioning

confidence: 99%

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Radio Frequency Coils for Hyperpolarized 13C Magnetic Resonance Experiments with a 3T MR Clinical Scanner: Experience from a Cardiovascular Lab

et al. 2021

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Hyperpolarized 13C magnetic resonance (MR) is a promising technique for the noninvasive assessment of the regional cardiac metabolism since it permits heart physiology studies in pig and mouse models. The main objective of the present study is to resume the work carried out at our electromagnetic laboratory in the field of radio frequency (RF) coil design, building, and testing. In this paper, first, we review the principles of RF coils, coil performance parameters, and estimation methods by using simulations, workbench, and MR imaging experiments. Then, we describe the simulation, design, and testing of different 13C coil configurations and acquisition settings for hyperpolarized studies on pig and mouse heart with a clinical 3T MRI scanner. The coil simulation is performed by developing a signal-to-noise ratio (SNR) model in terms of coil resistance, sample-induced resistance, and magnetic field pattern. Coil resistance was calculated from Ohm’s law and sample-induced resistances were estimated with a finite-difference time-domain (FDTD) algorithm. In contrast, the magnetic field per unit current was calculated by magnetostatic theory and a FDTD algorithm. The information could be of interest to graduate students and researchers working on the design and development of an MR coil to be used in 13C studies.

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Denoising of hyperpolarized ¹³C MR images of the human brain using patch‐based higher‐order singular value decomposition

Kim

Chen

Autry

et al. 2021

Magnetic Resonance in Med

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Purpose To improve hyperpolarized 13C (HP‐13C) MRI by image denoising with a new approach, patch‐based higher‐order singular value decomposition (HOSVD). Methods The benefit of using a patch‐based HOSVD method to denoise dynamic HP‐13C MR imaging data was investigated. Image quality and the accuracy of quantitative analyses following denoising were evaluated first using simulated data of [1‐13C]pyruvate and its metabolic product, [1‐13C]lactate, and compared the results to a global HOSVD method. The patch‐based HOSVD method was then applied to healthy volunteer HP [1‐13C]pyruvate EPI studies. Voxel‐wise kinetic modeling was performed on both non‐denoised and denoised data to compare the number of voxels quantifiable based on SNR criteria and fitting error. Results Simulation results demonstrated an 8‐fold increase in the calculated SNR of [1‐13C]pyruvate and [1‐13C]lactate with the patch‐based HOSVD denoising. The voxel‐wise quantification of kPL (pyruvate‐to‐lactate conversion rate) showed a 9‐fold decrease in standard errors for the fitted kPL after denoising. The patch‐based denoising performed superior to the global denoising in recovering kPL information. In volunteer data sets, [1‐13C]lactate and [13C]bicarbonate signals became distinguishable from noise across captured time points with over a 5‐fold apparent SNR gain. This resulted in >3‐fold increase in the number of voxels quantifiable for mapping kPB (pyruvate‐to‐bicarbonate conversion rate) and whole brain coverage for mapping kPL. Conclusions Sensitivity enhancement provided by this denoising significantly improved quantification of metabolite dynamics and could benefit future studies by improving image quality, enabling higher spatial resolution, and facilitating the extraction of metabolic information for clinical research.

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Multi-site benchmarking of clinical 13C RF coils at 3T

Abstract: Graphical abstract

Cited by 10 publications

References 36 publications

Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging

Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging

Radio Frequency Coils for Hyperpolarized 13C Magnetic Resonance Experiments with a 3T MR Clinical Scanner: Experience from a Cardiovascular Lab

Denoising of hyperpolarized ¹³C MR images of the human brain using patch‐based higher‐order singular value decomposition

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Multi-site benchmarking of clinical 13C RF coils at 3T

Abstract: Graphical abstract

Cited by 10 publications

References 36 publications

Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging

Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging

Radio Frequency Coils for Hyperpolarized 13C Magnetic Resonance Experiments with a 3T MR Clinical Scanner: Experience from a Cardiovascular Lab

Denoising of hyperpolarized 13C MR images of the human brain using patch‐based higher‐order singular value decomposition

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Denoising of hyperpolarized ¹³C MR images of the human brain using patch‐based higher‐order singular value decomposition