Multi-Solvent Microdroplet Evaporation: Modeling and Measurement of Spray-Drying Kinetics with Inhalable Pharmaceutics

Trileucine as a dispersibility enhancer of spray-dried inhalable microparticles

“…A comparative-kinetics electrodynamic balance was used to estimate the shell formation behavior of trileucine-containing systems. The evaporation and solidification behavior of single solution droplets (𝑑 0 ~50 μm) were analyzed in a comparative-kinetics electrodynamic balance [11,23,24]. For each experiment, a droplet-on-demand dispenser (MJ-ABP-01, MicroFab Technologies, Plano, Texas, USA) generated a single droplet, charged on generation by applying a DC voltage to an electrode near the tip.…”

“…These tools were previously used together successfully in explaining the particle formation of leucine [11]. A Comparative-Kinetics Electrodynamic Balance (CK-EDB) was used to measure the approximate time of shell formation from instantaneous sizing of single aerosol droplets trapped in a controlled environment [23,24]. A monodisperse droplet chain instrument was also used to collect the dried particles for electron microscopy and measurement of the particle densities [24][25][26].…”

Using Acetone/Water Binary Solvent to Enhance the Stability and Bioavailability of Spray Dried Enzalutamide/HPMC-AS Solid Dispersions

“…5,[7][8][9] To meet processability requirements such as minimal toxicity and residual levels, 10 water was used previously in preparing binary mixtures for spray-drying process. [11][12][13][14] It acts as a proton donor 2 to influence the hydrogen bonding between the drug and the polymer, which brings desirable benefits to form drug powders. For example, acetone/water (7:3) binary solvent was used to facilitate a ternary solid dispersion formulation of griseofulvin-PVP-PHPMA whose dissolution characteristics were improved since water is a good solvent for PVP.…”

Airborne virus transmission via respiratory droplets: Effects of droplet evaporation and sedimentation

“…Among these parameters, the relative humidity and the initial solute-volume fraction play key roles in determining the size of the droplet nuclei produced at the end of the evaporation process. Also, the morphology of the droplet nuclei is mainly controlled by the Péclet number [ 76 , 77 ], defined as the ratio of the particle-diffusion time inside the droplet to the droplet evaporation time [ 78 ], and the degree of saturation of the liquid solution [ 76 ]. The experimental results suggest that morphological and physical-chemical changes occurring during droplet evaporation may affect the viability of viruses and pathogens contained within the droplet [ 60 ] and, thus, influence the efficiency of airborne transmission of infectious diseases.…”