In the process of product design, design changes are unavoidable due to the diversification of customer requirements and the advancement of key technologies. Although modules are supposed to be functionally independent and “low-coupling” in modular products, the design change in a module can still propagate into other modules due to the interfaces among them, and this propagation increases the product development lead-time and costs. This study aims to solve the problem of cross-module propagation in design change. First, the dependence of modules on interfaces is analyzed from the perspectives of complex network characteristics, change propagation characteristics, and cost dependence, and then the correlation between modules is determined. Second, the cross-module change propagation impact is evaluated considering node importance, change cost, and propagation path length. The control strategies of cross-module design change propagation are proposed from the aspects of increasing the tolerance of interface and reducing the dependence of modules on interface, etc. Finally, a certain type of sanitation vehicle cab is utilized as an example to demonstrate the assessment process of the cross-module propagation impact of design change and to verify the feasibility of the proposed method and control strategies.