Population growth, urbanization, and climate change have significantly contributed to environmental degradation, posing severe consequences for humans and other species. By integrating ecological objectives with human-centric goals, a path towards a sustainable, multi-species future is possible. Current sustainable design principles have shown positive environmental impacts by addressing human-centric objectives such as enhancing green infrastructure, energy efficiency, thermal comfort, and more. However, the incorporation of multi-species design criteria remains unresolved. This paper proposes a conceptual framework in which human-centric and ecological design objectives are defined and associated through the selection of key performance indicators (KPIs) represented by numerical thresholds. But, while the objective-KPI relationship is an established path in architectural design, the same does not apply for preserving and promoting biodiversity. The proposed conceptual framework identifies, defines, and associates the relevant objective-KPI relationships for all stakeholders and becomes the basis for evaluating the project computationally. Such an approach is currently lacking.