“…This encourages future work that exceeds beyond traditional randomized controlled study designs, enabling the expression ( 12 ) and systematic study of complex system configurations and mechanisms for adaptivity. This will require capable and scalable research infrastructures ( 13 ), as well as improvements in research methods at scale, for which novel artificial intelligence methods currently offer an exciting avenue of exploration, particularly due to newly evolving capabilities in readily integrating highly varied and sparse multi-modal data streams, as well as converting between structured digital (i.e., “computable”) and unstructured natural language (i.e., easily and efficiently describable) representations.…”