This review article investigates the effects of the COVID-19 pandemic on female workers in the global supply chain context. To this end, we reviewed and critically examined emerging scholarly literature as well as policy documents and reports published by international development organizations concerning female workers’ social sustainability, livelihood, and health and wellbeing issues in global supply chain operations. Thus, this article focuses on female workers’ issues in emerging and developing economies where the ongoing pandemic continues to devastate and create multidimensional social and economic challenges for the wellbeing and social sustainability of female workers. Our analysis suggests that female workers are facing serious socioeconomic challenges that continue to affect their wellbeing, mental health, and livelihoods. Accordingly, it is imperative that international development organizations, non-governmental organizations (NGOs), trade associations, governments, and most importantly the corporate sector not only consider individual responsibility for promoting female workforce social sustainability in global supply chains but also actively collaborate to address pressing social sustainability issues vis à vis female workers. Building on these findings, the implications for future research, practice, and policies are discussed.