Multi-step fluorescence resonance energy transfer between the fluorophores via cosolubilization in cationic, anionic and non-ionic micelles

Afzal, Saima; Lone, Mohd Sajid; Bhat, Parvaiz Ahmad; Dar, Aijaz Ahmad

doi:10.1016/j.jphotochem.2018.08.002

Cited by 19 publications

(12 citation statements)

References 48 publications

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“…It is well known that the surfactant-based self-assembled systems can solubilize and compartmentalize the organic molecules which result in excluding the molecules from the effect of species in the bulk aqueous solution. − However, the extent and site of solubilization of the solubilizate are highly dependent on the nature of the solubilizate and the micelles. ,, Therefore, to prevent the attack of the hydroxide ions on UMB , we tried three different surfactant systems, namely, a neutral surfactant Brij 30 , a cationic surfactant tetradecyltrimethylammonium bromide (TTAB), and an anionic surfactant sodium dodecyl sulfate (SDS) (Figure S3).…”

Section: Resultsmentioning

confidence: 99%

“…68−70 However, the extent and site of solubilization of the solubilizate are highly dependent on the nature of the solubilizate and the micelles. 60,68,71 Therefore, to prevent the attack of the hydroxide ions on UMB, we tried three different surfactant systems, namely, a neutral surfactant Brij 30, a cationic surfactant tetradecyltrimethylammonium bromide (TTAB), and an anionic surfactant sodium dodecyl sulfate (SDS) (Figure S3).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The quantum yields were calculated using the following equation with the quantum yield of Rhodamine 6G (R6G) in methanol (0.92) taken as a reference where ⌀ denotes the quantum yield and the subscripts “s” and “r” refer to sample and reference, respectively. “ A ” represents the area under the emission curve of the fluorophore, and “Abs” and “ n ” represent the absorbance and refractive index of the solvent, respectively.…”

Section: Methodsmentioning

confidence: 99%

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Emission Color Tuning and White Light Generation from a Trimolecular Cocktail in Cationic Micellar System with Promising Applicability in the Anticounterfeiting Technology

Ahanger

Nazir²,

Lone

et al. 2021

Langmuir

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The development of photoluminescent (PL) systems, displaying multiple stimuli-responsive emission color tuning, has been the pressing priority in the recent times due to their huge role in contemporary lighting and anticounterfeiting technologies. Acknowledging this importance, we present a simple and eco-friendly PL system showing emission color tuning in response to different stimuli, that is, the composition of the system, pH, excitation wavelength, and the temperature with the plus point of getting significantly pure white light emission (WLE). The novel system is fabricated from the aqueous mixture of three organic fluorophores, umbelliferone (UMB), fluorescein (FLU), and Rhodamine-B (RB). By varying the fluorophore composition in the mixture at pH 12, nearly pure WLE with a Commission Internationale d'Eclairage (CIE) 1931 profile of (0.33, 0.33) was obtained at the excitation wavelength of 365 nm, the sustainability of which was ensured by employing the micellar self-assemblies of tetradecyltrimethylammonium bromide (TTAB) molecules. Similar WLE was obtained under mildly acidic conditions (pH 6) but at the excitation wavelength of 330 nm. By proper tuning of pH and the wavelengths of the system to use it as a fluorescent ink, we found a remarkable and highly applicable phenomenon observed for the first time, that is, triple-mode orthogonal emission color tuning with white light ON/OFF switching. We validate the vital applicability of this phenomenon in protecting the authenticity of the document with its hard-to-counterfeit property. The applicability of this phenomenon is also explored by synthesizing PVA-based fluorescent films from the tri-fluorophore mixture. Moreover, the emission color of the PL system was explored lucidly for its temperature dependence owing to the thermal responsiveness of RB emission, where the PL system proves to be a full-color RGB system.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Emission Color Tuning and White Light Generation from a Trimolecular Cocktail in Cationic Micellar System with Promising Applicability in the Anticounterfeiting Technology

Ahanger

Nazir²,

Lone

et al. 2021

Langmuir

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“…In order to observe the distribution of polymeric nanoparticles in vivo and in vitro, traditional fluorescent dyes such as rhodamine, cyanine, fluorescein isothiocyanate (FITC) and quantum dots are widely introduced in DDS for imaging. For further clarification about intracellular antitumor drug release from DDS, we recommend the fluorescence resonance energy transfer (FRET) effect between drug and drug carrier, as FRET is a commonly used technological means to evaluate the distance between the pair of two fluorescent chromophores in biological sciences and extensively researched the interaction between some biomolecules and proteins [22–24]. A handful of articles have been employed for monitoring drug release used above mentioned traditional fluorescent dyes [25, 26].…”

Section: Introductionmentioning

confidence: 99%

Intracellular tracking of drug release from pH-sensitive polymeric nanoparticles via FRET for synergistic chemo-photodynamic therapy

Liang

et al. 2019

J Nanobiotechnol

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BackgroundSynergistic therapy of tumor is a promising way in curing cancer and in order to achieve effective tumor therapy with real-time drug release monitoring, dynamic cellular imaging and antitumor activity.ResultsIn this work, a polymeric nanoparticle with Forster resonance energy transfer (FRET) effect and chemo-photodynamic properties was fabricated as the drug vehicle. An amphiphilic polymer of cyclo(RGDfCSH) (cRGD)-poly(ethylene glycol) (PEG)-Poly(l-histidine) (PH)-poly(ε-caprolactone) (PCL)-Protoporphyrin (Por)-acting as both a photosensitizer for photodynamic therapy (PDT) and absorption of acceptor in FRET was synthesized and self-assembled into polymeric nanoparticles with epirubicin (EPI)-acting as an antitumor drug for chemotherapy and fluorescence of donor in FRET. Spherical EPI-loaded nanoparticles with the average size of 150 ± 2.4 nm was procured with negatively charged surface, pH sensitivity and high drug loading content (14.9 ± 1.5%). The cellular uptake of EPI-loaded cRGD-PEG-PH-PCL-Por was monitored in real time by the FRET effect between EPI and cRGD-PEG-PH-PCL-Por. The polymeric nanoparticles combined PDT and chemotherapy showed significant anticancer activity both in vitro (IC50 = 0.47 μg/mL) and better therapeutic efficacy than that of free EPI in vivo.ConclusionsThis work provided a versatile strategy to fabricate nanoassemblies for intracellular tracking of drug release and synergistic chemo-photodynamic therapy.

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“…Fluorescence resonance energy transfer (FRET) is a distance-dependent photophysical process by which energy is transferred nonradiatively from an excited fluorophore (donor) to a proximal ground state fluorophore (acceptor) by means of an intermolecular long-range dipole–dipole coupling. The applications of conventional single-step FRET systems are limited, as these provide localized color changes with outputs based on only one donor and one acceptor. − The multistep FRET systems, on the other hand, involve funneling of energy through a systematic array of three or more spatially oriented fluorophores − having excellent usage in the development of photoluminescent materials with color tunability, photovoltaic devices, light emitting devices, multicolor bioimaging, photodynamic therapy, biosensing, − and security printing . In order to achieve the spatial orientation of such multichromophoric arrays, scaffolds like DNA, dendrimers, proteins, and other biological assemblies have been used for inducing energy transfer utilizing either covalent or non-covalent interactions .…”

Section: Introductionmentioning

confidence: 99%

Broad Spectrum Tunable Photoluminescent Material Based on Cascade Fluorescence Resonance Energy Transfer between Three Fluorophores Encapsulated within the Self-Assembled Surfactant Systems

et al. 2019

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A broad spectrum tunable photoluminescent material with dual encryption based on a two-step fluorescence resonance energy transfer (FRET) between pyrene (Py), coumarin 480 (Cou480), and rhodamine 6G (R6G) in micelles of SDS and bmimDS is presented. The phenomenon is achievable due to the encapsulation of the fluorophores within these micelles. The transfer of energy as FRET between the pair Py and Cou480 showed ON at 336 nm and OFF at 402 nm in contrast to the FRET observed between the pair Cou480 and R6G that showed ON at 402 nm and OFF at 336 nm. However, the transfer of energy as FRET occurs from Py to R6G in the presence of Cou480 when excited at 336 nm, thereby making it a chain of three fluorophores with Cou480 acting as a relay fluorophore receiving energy from Py and transferring it to R6G. The different FRET scenarios between the three fluorophores in micelles provide a window for the generation of a matrix of colors, which occupies a significant 2D area in the chromaticity diagram, having potential applications in security printing. The different fluorophoric ratios generate different colors based on their individual photonic emissions and the FRET processes taking place between them. Writing tests were carried out using varied ratios of the fluorophores in the micellar systems producing different colored outputs under the UV light with insignificant visibility under the white light. We envision that this as-discovered three fluorophoric FRET system could form the basis for the future development of multi-FRET lightharvesting devices and anti-counterfeiting security inks based on much simpler non-covalent interaction aided encapsulation of the fluorophores within the self-assembled soft systems.

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Multi-step fluorescence resonance energy transfer between the fluorophores via cosolubilization in cationic, anionic and non-ionic micelles

Cited by 19 publications

References 48 publications

Emission Color Tuning and White Light Generation from a Trimolecular Cocktail in Cationic Micellar System with Promising Applicability in the Anticounterfeiting Technology

Emission Color Tuning and White Light Generation from a Trimolecular Cocktail in Cationic Micellar System with Promising Applicability in the Anticounterfeiting Technology

Intracellular tracking of drug release from pH-sensitive polymeric nanoparticles via FRET for synergistic chemo-photodynamic therapy

Broad Spectrum Tunable Photoluminescent Material Based on Cascade Fluorescence Resonance Energy Transfer between Three Fluorophores Encapsulated within the Self-Assembled Surfactant Systems

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