Diabetes Clinical Research important task is to monitor and prevent the occurrence of high / low blood sugar events. Glucose monitoring system (Continous Glucose Monitoring System, CGMS) is used clinically in recent years gradually new blood glucose monitoring system, by measuring the concentration of glucose in interstitial fluid glucose fluctuations throughout the day to indirectly reflect the whole picture. It can be 30 minutes early to predict blood glucose levels as well as low blood sugar warning. Based on time-series modeling techniques, with blood glucose levels for non-stationary paper with improved self-regression model (AR) on blood glucose prediction. And the order of the model parameters were determined by the least squares method and adaptive AIC criteria. The results show that the algorithm can be based on time series modeling real-time and accurate display changes in blood glucose levels, while forecasting and early warning of low blood sugar glucose results showed good performance.