Multi-strain modeling of influenza vaccine effectiveness in older adults and its dependence on antigenic distance
Severine Urdy,
Matthias Hanke,
Ana I. Toledo
et al.
Abstract:Influenza vaccine effectiveness (VE) varies seasonally due to host, virus and vaccine characteristics. To investigate how antigenic matching and dosage impact VE, we developed a mechanistic knowledge-based mathematical model. Immunization with a split vaccine is modeled for exposure to A/H1N1 or A/H3N2 virus strains. The model accounts for cross-reactivity of immune cells elicited during previous immunizations with new antigens. We simulated vaccine effectiveness (sVE) of high dose (HD) versus standard dose (S… Show more
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