Multi‐system progressive angiomatosis in a dog resembling blue rubber bleb nevus syndrome in humans

Ide, Kaori; Uchida, Noriyuki; Iyori, Keita; Mochizuki, Takako; Fukushima, Ryuji; Iwasaki, Tadaaki; Nishifuji, Koji

doi:10.1111/jsap.12034

Cited by 11 publications

(16 citation statements)

References 20 publications

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“…Vertebral angiomatosis is a rare vascular malformation with few cases reported in the literature. 1 – 5 In dogs several forms of angiomatosis have been reported including cutaneous, 6 , 7 cardiac, 8 meningeal, 9 skeletal 10 and multisystemic forms, 11 whereas in cats it is a little-known disorder. 12 In terms of spinal cord disease in cats or, in general, neurological disorders in feline species, this disease has not previously been considered.…”

Section: Introductionmentioning

confidence: 99%

Feline vertebral angiomatosis: two cases

Frizzi

Ottolini

Spigolon³

et al. 2017

Journal of Feline Medicine and Surgery Open Reports

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Case series summaryTwo cats aged between 1 and 2 years were presented for paraparesis, general discomfort, back pain and urinary retention. Extradural spinal cord compression at the level of T4 and T8 was evident on CT examination and on MRI. Hemilaminectomy and partial corpectomy were performed to achieve spinal cord decompression. Histopathology of the abnormal bone tissue was suggestive of vertebral angiomatosis. After initially worsening, both cats recovered their normal gait and functional urination. Both cats have been followed-up for >1 year, without any recurrence.Relevance and novel informationThis is the first report of vertebral angiomatosis with complete data (CT, MRI, surgical procedures, histopathology and >1 year follow-up) and provides important information about the prognosis of this rare vascular malformation.

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Section: Introductionmentioning

confidence: 99%

Feline vertebral angiomatosis: two cases

Frizzi

Ottolini

Spigolon³

et al. 2017

Journal of Feline Medicine and Surgery Open Reports

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“…However, vascular malformations have been reported to have a progressive behaviour and a tendency to expand into surrounding tissues [2,25,26]. Progressive angiomatosis is well known for its invasive behaviour, which is also described in previous cases of canine vascular-and lymphatic malformations [8,9,25]. Thus, differentiation between a tumor and a vascular malformation can be challenging.…”

Section: Discussionmentioning

confidence: 99%

“…A review of the veterinary literature suggests that the vast majority of vascular malformations are of blood vessel origin [5][6][7][8][9][10][11][12][13][14][15]. Only few reports confirm a lymphatic vessel origin of vascular malformations in the skin, intestines, liver and mammary gland [16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Retroperitoneal lymphatic malformation in a dog

Driessen

Cushing²

2020

Acta Vet Scand

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Background: Lymphatic vascular malformations are rare findings in canine patients with six reports available in veterinary literature. Retroperitoneal cystic lymphatic malformations have not been described previously in canine patients and neither has the use of immunohistochemistry to determine their origin, i.e. vascular versus lymphatic. Case presentation: An 8-year-old neutered female Cocker spaniel was referred for pollakiuria, dysuria and a painful abdomen. Computed tomography scanning of the abdomen showed a fluid filled structure adjacent to the urinary bladder. During surgical exploration, a thin walled cystic structure with sero-haemorrhagic fluid was found, extending from the retroperitoneal space into the abdomen. The mass was excised and submitted for histopathology, revealing a cystic mass lined by a fibrovascular capsule within the retroperitoneal/mesenteric adipose tissue. The inner surface of the cyst was lined by a single layer of bland, flattened spindle cells. Intramural blood vessels were well differentiated, with perivascular haemorrhage. On recurrence 11 months later, the mass was excised for the second time and a PleuralPort (Norfolk Animal products) was placed. Fifteen months after initial presentation, progression occurred with haemorrhagic fluid in the cystic space, pleural-and abdominal cavities and the owners opted for euthanasia. Histopathology and positive immunohistochemistry for lymphatic markers lymphatic vessel endothelial hyaluronic acid receptor-1 (LYVE-1) and prospero homeobox protein-1 (PROX-1) confirmed a lymphatic vascular origin of the cystic structure. Conclusions: To our experience, a definitive diagnosis of retroperitoneal cystic malformation of lymphatic origin could be done only by combining the clinical presentation, advanced imaging, histopathology and LYVE-1 and PROX-1 immunohistochemistry. This is the first report of a vascular malformation in a dog where immunohistochemistry was used to make a final diagnosis. A lymphatic malformation, even if rare, should be added on the list of the differential diagnosis in a patient with a retroperitoneal cystic structure containing serohaemorrhagic fluid. Results of this case report can aid in diagnosis of future cases, however, further studies on therapy and management are needed to provide additional information about optimal treatment of these patients.

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“…Clinical forms of angiomatosis have previously been recognised in dogs. These include cutaneous angiomatosis (Peavy and others 2001, Kim and others 2005, Olivieri and others 2010), scrotal-type vascular hamartoma or progressive angiomatosis, in which the lesions were mainly on the scrotal area and acral areas or face, respectively (Gross and others 2005, Olivieri and others 2010), skeletal–extraskeletal angiomatosis (Kuroki and others 2010), and multisystem progressive angiomatosis where the lesions were mainly cutaneous, oesophageal or gastrointestinal, or on the visceral peritoneal lining of abdominal organs (Ide and others 2013). Gal and others (2013) reported a case of splenic littoral cell angiosarcoma in a beagle.…”

Section: Discussionmentioning

confidence: 99%

A case of isolated diffuse splenic haemangiomatosis in a dog

Murgia¹,

Mori²,

Rondena³

et al. 2015

Vet Record Case Reports

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This report describes a case of isolated diffuse haemangiomatosis in the spleen of a nine‐month‐old dog that presented with weakness, abdominal discomfort and severe splenomegaly. Histopathological examination following splenectomy showed the splenic parenchyma had almost been replaced by multiple dilated vascular lacunae, varying is size, and lined by a single layer of flattened, well differentiated, endothelial cells sustained by fine fibrocystic bundles. The cytoplasmic expression of CD34 and von Willebrand factor found in the endothelial cells confirmed the vascular nature of the lesion; the lack of expression of podoplanin, a specific marker for the lymphatic vessels, excluded the diagnosis of lymphangiomatosis. Diffuse splenic haemangiomatosis carries a benign prognosis and complete cure following splenectomy has been described in humans and was achieved in this case. However, the differential diagnosis must take into account the possibility of vascular malignant or tumour‐like lesions occurring in the spleen.

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Multi‐system progressive angiomatosis in a dog resembling blue rubber bleb nevus syndrome in humans

Cited by 11 publications

References 20 publications

Feline vertebral angiomatosis: two cases

Feline vertebral angiomatosis: two cases

Retroperitoneal lymphatic malformation in a dog

A case of isolated diffuse splenic haemangiomatosis in a dog

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