Multi-Target Approach of Murraya koenigii Leaves in Treating Neurodegenerative Diseases

Tan, Mario A.; Sharma, Niti; An, Seong Soo A.

doi:10.3390/ph15020188

Cited by 18 publications

(7 citation statements)

References 109 publications

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“…MKEO is medicinally used to treat osteoporosis, chemotherapy treatments of cancers, and wound healing along with antimicrobial, antioxidant, antioxidant, antifungal, and antibacterial activity (12,13) . Monoterpenes and sesquiterpenes were identified in GCMS analysis of MKEO among which ß-Caryophyllene(13.28%), Sabinene(12.54%), Gurjunene(6.24%) were shown in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

Predicting Antioxidant, Neuroprotective, and Toxicity Activity of Murraya koenigii Essential Oil by in silico and ex vivo against Rotenone-induced Model

Sireesha,

Vidyavathi

2023

IJST

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Objectives: To study the antioxidant capacity of Murraya koeingii essential oil (MKEO) phytoconstituents Methods: It was determined by using GCMS. The phytoconstituents were then exposed to molecular docking studies that targeted dopamine D2 to look for neuroprotective effects. The highest percentage content of constituents were selected as ligands and dopamine(6VMS) was retrieved from the protein data bank, the docking was performed using Schrodinger software version 2021-4. The pharmacokinetic profile associated with the selected components were predicted utilizing ADMET lab 2.0 and pkCSM which is a graph-based small molecular pk predictor along with toxicity properties of constituents. The neuroprotective activity of MKEO is also predicted by Ex vivo protocol using rotenone as an inducing agent in mice brain slices. Findings: The antioxidant potentials were nearer to the positive control (Ascorbic acid) which proved the antioxidant capacity of MKEO. The antioxidant enzymes of CAT and GSH were also decreased in the mice brain slices which are treated with rotenone and LPO values were decreased. The levels of dopamine, CAT, and GSH were improved in the groups supplemented with MKEO at different concentrations, along with reduced LPO levels. Novelty: These results are reassuring that both In silico and Ex vivo investigations had greater neuroprotective and antioxidant activities for the phytoconstituents examined from MKEO.

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Section: Resultsmentioning

confidence: 99%

Predicting Antioxidant, Neuroprotective, and Toxicity Activity of Murraya koenigii Essential Oil by in silico and ex vivo against Rotenone-induced Model

Sireesha,

Vidyavathi

2023

IJST

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“… Rats & humans [ 197 , 198 ] Murraya koenigii (Rutaceae) Leaves extract Carbazole alkaloids, Scoponin It reduces the ChEs action in the hippocampus region of the brain to increase the nootropic effect. Enzyme, mice and oxidative stress markers [ 199 , 200 ] Cassia obtusifolia (Legumes) Seed extract Gluco-obtusifolin, Obtusifolin It increases the ACh level through inhibition of AChE. Mice [ 201 , 202 ] Centella asiatica (Umbellifers) Extract of whole plant Triterpene glycosides, saponins It increases the ACh level through inhibition of AChE and also reduces the formation of Aβ plaques.…”

Section: Current Neurotherapeutics For Admentioning

confidence: 99%

Review of Pharmacotherapeutic Targets in Alzheimer’s Disease and Its Management Using Traditional Medicinal Plants

Tripathi,

Lodhi,

Rai

et al. 2024

DNND

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. While there is currently no cure for AD, several pharmacotherapeutic targets and management strategies have been explored. Additionally, traditional medicinal plants have gained attention for their potential role in AD management. Pharmacotherapeutic targets in AD include amyloid-beta (Aβ) aggregation, tau protein hyperphosphorylation, neuroinflammation, oxidative stress, and cholinergic dysfunction. Traditional medicinal plants, such as Ginkgo biloba, Huperzia serrata, Curcuma longa (turmeric), and Panax ginseng, have demonstrated the ability to modulate these targets through their bioactive compounds. Ginkgo biloba , for instance, contains flavonoids and terpenoids that exhibit neuroprotective effects by reducing Aβ deposition and enhancing cerebral blood flow. Huperzia serrata , a natural source of huperzine A, has acetylcholinesterase-inhibiting properties, thus improving cholinergic function. Curcuma longa , enriched with curcumin, exhibits anti-inflammatory and antioxidant effects, potentially mitigating neuroinflammation and oxidative stress. Panax ginseng’s ginsenosides have shown neuroprotective and anti-amyloidogenic properties. The investigation of traditional medicinal plants as a complementary approach to AD management offers several advantages, including a lower risk of adverse effects and potential multi-target interactions. Furthermore, the cultural knowledge and utilization of these plants provide a rich source of information for the development of new therapies. However, further research is necessary to elucidate the precise mechanisms of action, standardize preparations, and assess the safety and efficacy of these natural remedies. Integrating traditional medicinal-plant-based therapies with modern pharmacotherapies may hold the key to a more comprehensive and effective approach to AD treatment. This review aims to explore the pharmacotherapeutic targets in AD and assess the potential of traditional medicinal plants in its management.

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“…They are also present in a wide variety of fruits and vegetables. Multiple phenolic groups are found in polyphenols, which are known to have anti-inflammatory, antioxidant, and anti-cancer effects 117 . Terpenoids, which are chemicals formed from isoprene units with five carbons, are well-recognized for having antibacterial and antifungal effects 118 .…”

Section: Phytochemical Constituents and Its Medicinal Propertiesmentioning

confidence: 99%

Venom Vanquish: A Comprehensive Review on Ethnobotany and Phytochemistry of Significant Traditional Medicinal Plants

T. Dhanya,

Kavinila,

David Paul Raj

2024

JNR

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Snakebite is a significant public health concern in many parts of the world, particularly in regions where venomous snakes are prevalent. Snakebites can range from mild to life-threatening, depending on the species of snake, the amount of venom injected, and the location of the bite. Globally, an estimated 5 million people are affected by snake bites each year, according to recent statistics. Since ancient times, traditional medicinal plants have been used to cure a wide range of illnesses, including snake bites. Secondary metabolites contained in plants were efficient in reducing the effects of snake venom. Snake venom is a potent toxin that can cause severe damage to the human body, affecting the nervous system, cardiovascular system, or both. Symptoms can range from mild swelling to life-threatening paralysis, respiratory failure, and hemorrhage. Enzyme activity is inhibited by flavonoids, alkaloids, and tannins, which additionally hinder blood from clotting and lessen inflammation. Treatments for snake bites that are more beneficial and less hazardous could result from the isolation and synthesis of natural drugs. With the use of cutting-edge scientific methods, we can maximize their potential and use their secondary metabolites to develop novel medications and therapies. The study of these plants and their potential uses in contemporary medicine requires more funding and investigation. This will advance our knowledge of these plants and help us create cures for some of the most lethal diseases.

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Multi-Target Approach of Murraya koenigii Leaves in Treating Neurodegenerative Diseases

Cited by 18 publications

References 109 publications

Predicting Antioxidant, Neuroprotective, and Toxicity Activity of Murraya koenigii Essential Oil by in silico and ex vivo against Rotenone-induced Model

Predicting Antioxidant, Neuroprotective, and Toxicity Activity of Murraya koenigii Essential Oil by in silico and ex vivo against Rotenone-induced Model

Review of Pharmacotherapeutic Targets in Alzheimer’s Disease and Its Management Using Traditional Medicinal Plants

Venom Vanquish: A Comprehensive Review on Ethnobotany and Phytochemistry of Significant Traditional Medicinal Plants

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