Multi-Targeted Molecular Effects of Hibiscus sabdariffa Polyphenols: An Opportunity for a Global Approach to Obesity

Abstract

Improper diet can alter gene expression by breaking the energy balance equation and changing metabolic and oxidative stress biomarkers, which can result in the development of obesity-related metabolic disorders. The pleiotropic effects of dietary plant polyphenols are capable of counteracting by modulating different key molecular targets at the cell, as well as through epigenetic modifications. Hibiscus sabdariffa (HS)-derived polyphenols are known to ameliorate various obesity-related conditions. Recent evidence leads to propose the complex nature of the underlying mechanism of action. This multi-targeted mechanism includes the regulation of energy metabolism, oxidative stress and inflammatory pathways, transcription factors, hormones and peptides, digestive enzymes, as well as epigenetic modifications. This article reviews the accumulated evidence on the multiple anti-obesity effects of HS polyphenols in cell and animal models, as well as in humans, and its putative molecular targets. In silico studies reveal the capacity of several HS polyphenols to act as putative ligands for different digestive and metabolic enzymes, which may also deserve further attention. Therefore, a global approach including integrated and networked omics techniques, virtual screening and epigenetic analysis is necessary to fully understand the molecular mechanisms of HS polyphenols and metabolites involved, as well as their possible implications in the design of safe and effective polyphenolic formulations for obesity.

Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial

“…Considering the accumulated evidence on the effects of plant-derived polyphenols on obesity models, we proposed that some specifically designed nutraceuticals based on polyphenolic extracts may offer additional support for these particular patients in the management of obesity. 17,20,23 Over the years, scientific evidence has shown that polyphenolic extracts from plant sources may be valuable tools to treat obesity. 24 In this regard, our research at the pre-clinical and clinical level has shown the efficiency of the polyphenolic extracts from LC and HS.…”

“…Recent in vitro studies suggest that polyphenolic extracts from Lippia citriodora (LC) and Hibiscus sabdariffa (HS) reduce intracellular lipid accumulation and decrease high glucose-induced oxidative stress and inflammation in adipose tissue through the regulation of different metabolic pathways. [12][13][14][15][16][17] The accumulated evidence suggests that a multi-targeted mechanism (regulation of signaling and energy-sensitive pathways, oxidative stress and inflammation-related processes, mitochondrial functionality and membrane-dependent processes) is involved rather than the simple modulation of oxidative stress. [17][18][19][20] Most of these effects have been corroborated in hyperlipidemic animal models in which the continuous consumption of these polyphenolic extracts prevented fatty liver disease and improved lipid metabolism.…”

Effect of roselle extracts on the selected quality characteristics of ice cream

“…In Sudan, the leaves of roselle are consumed as either a fresh or dried vegetable that is cooked with onion and groundnuts [13] Roselle leaves are consumed as a vegetable in Malaysia and Nigeria, [13,14] where they are also used for making jam because of their high pectin content. [15] Its brilliant red petals are usually processed into unique and refreshing alcoholic and non-alcoholic drinks. [16] The extracts from roselle calyces are consumed across the world as either a cold beverage or a hot drink.…”

Effect of Hibiscus sabdariffa (Roselle) supplementation in regulating blood lipids among patients with metabolic syndrome and related disorders: A systematic review and meta‐analysis

“…In ancient times, H. sabdariffa was mainly used for treating inflammatory, neurological, and cardiac diseases (Da‐Costa‐Rocha, Bonnlaender, Sievers, Pischel, & Heinrich, ). In recent years, numerous experimental studies have confirmed its exact pharmacological effects in regulating blood lipids among subjects with metabolic disorders, which may be closely associated with its antioxidant and anti‐inflammatory activities, as well as the regulatory role in energy metabolism and hormone secretion (Herranz‐Lopez et al, ). Accumulating evidence suggests that polyphenols, polysaccharides, anthocyanins, and other bioactive constituents contained in it maybe the material basis of the multipathway therapeutic effects (Da‐Costa‐Rocha et al, ).…”