The effects of irregular population growth, migration mobility, and vegetation dynamics by humans can lead to changes in Land Use and Land Cover (LULC). Changes in LULC are particularly significant in coastal areas associated with industrial activities. The South-Eastern Marmara region, which is one of Turkey's important industrial coastal areas, is also affected by the surrounding changes. The study area was selected on purposes to determine LULC change and accuracy of classification using Sentinel-2 based vegetation indices combinations. In study area, the Gemlik-Bursa Northern Interchange investments area and newly construction of the TOGG (Turkey's Automobile Initiative Group) factory are located. The study area was determined by creating a 5 km buffer zone from the coast to the mainland in the area covering the Armutlu district of Yalova province and the Osmangazi, Mudanya, and Gemlik districts of Bursa province. The RF (Random Forest) classification technique has been applied to original bands and combination of 21 new bands using indices obtained from satellite images for 3 seasons in 2016 and 2020. The highest accuracy results for the winter, spring, and summer seasons of 2016 were observed in OI12 (%82,93), ORF (%84,44), and again ORF (%84,67) indices, while in 2020, they were observed in OI5 (%85,89), ORF (%84,75), and OI6 (%84,63) indices. The main reason for changes in classification accuracy due to the influence of different bands is understood to be the interaction between the LULC on the ground in the season when the image was acquired and the characteristics in the bands. It was determined that the changes in LULC in the South-Eastern Marmara would be due to investment decisions taken in the region, resulting population growth, and pixel-based classification errors due to spectral reflections in some areas.