Multi-variate ranking function for optimizing separations

Chromatographic response functions in 1D and 2D chromatography as tools for assessing chemical complexity

“…The CRF described by Equation (10) in Table 2 is known as the chromatography resolution statistic (CRS), and it was introduced by Schlabach and Excoffier [30]. This function can be divided into three different factors: the first factor allows the optimization to proceed until a minimum of 0, when the separation measure used (the IUPAC resolution) reaches the optimal resolution predetermined by the analyst; the second factor uses an average resolution value, and attempts to ensure a uniform separation along the chromatogram; and, the third factor (t L /N) is a multiplicative factor that increases the value of CRS when the time of analysis increases and the number of peaks decreases [4].…”

Microemulsion electrokinetic chromatography of drugs varying in charge and hydrophobicity Part II: Strategies for optimization of separation

“…(ii) The chromatographic functions CRF [10][11][12][13], CRS [10,14], CEF [10,15,16], COF [10,17], ATR [18], Rp [19], and r [20] were calculated according to Eq. (5)- (10) within each group and used as a response in MODDE.…”

“…Furthermore, different strategies for optimization of the separation were investigated. The compounds were divided into five subgroups and each group was optimized separately by maximizing the selectivity of the critical peak pair using response surface plots in MODDE, by calculating the chromatographic response function (CRF) [10][11][12][13], chromatographic resolution statistic (CRS) [10,14], chromatographic exponential function (CEF) [10,[15][16], chromatographic optimization function (COF) [10,17], arcs tangens resolution (ATR) [18], resolution product (Rp) [19] and relative resolution product (r) [20], and by using the software DryLab  [21][22][23][24][25][26][27]. CRF, CEF, COF, ATR, and r have all been used for optimization of separation in electrodriven techniques.…”

Experimental design as a tool when evaluating stationary phases for the capillary electrochromatographic separation of basic peptides

“…Many different chromatographic functions have been described in the literature [25][26][27][28][29][30][31][32][33][34], however, only the chromatographic optimisation function, COF, the chromatographic response function, CRF 3 (modified according to [29]), and the resolution product, R p were used here. The chromatographic functions were calculated according to equations (3)-(5):…”