Abstract. This paper investigates the influence of different combinations of second-order (β 2 ), fourth-order (β 4 ) and sixth-order (β 6 ) dispersion coefficient signs (negativity/positivity) to the fiber optical parametric amplifier gain performance. The numerical simulation has exploited the fourth-order Runge-Kutta method to solve the coupled amplitude equations which basically represent the parametric process of four-wave mixing. In the normal regime at which β 2 is positive, the fiber optical parametric amplifier exhibits a poor gain spectrum and it is well performed once the pump is presumed to be in anomalous regime i.e. β 2 is negative. The effect of β 4 is significant when the signal wavelength is further from the pump wavelength and a wide amplification bandwidth is produced when the fiber have positive β 4 in the anomalous regime. As for β 6 , unfortunately in this simulation its influences are hardly can be seen probably because of its small value regardless its sign, but, from phase-mismatch equation it is shown that its impact is prominent when the signal is positioned way far from the pump. All in all, this shown that the signs combination of the higher-order dispersion coefficients are significant in order to optimize the FOPA amplification bandwidth.