Multiangle Long-Axis Lateral Illumination Photoacoustic Imaging to Evaluate Tumor Oxygenation

Uliana, João H.; Candido, Marina Ferreira; Brassesco, María Sol; Carneiro, Antônio Adilton Oliveira; Pavan, Theo Z.

doi:10.1109/laus53676.2021.9639188

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…The probe structure includes a motor that allows precise angular illumination, however, this approach makes the probe bulkier and changing the angle of illumination impractical in clinical setup. Similar studies were also performed in References [20][21][22][23][24] and the probe structure was simple and compatible for clinical use. However, the angular adjustment was either not flexible (need to replace probe heads or rotate the imaging target) and/or required precise calibration to keep the focal point in the plane of imaging.…”

Section: Introductionmentioning

confidence: 63%

Randomized multi‐angle illumination for improved linear array photoacoustic computed tomography in brain

Manwar

Lara

Prakash

et al. 2022

Journal of Biophotonics

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One of the key challenges in linear array transducer‐based photoacoustic computed tomography is to image structures embedded deep within the biological tissue with limited optical energy. Here, we utilized a manually controlled multi‐angle illumination technique to allow the incident photons to interact with the imaging targets for longer periods of time and diffuse further in all directions. We have developed and optimized a compact probe that enables manual changes to the angle of illumination while acquiring photoacoustic signals. The performance has been demonstrated and evaluated by imaging complex blood vessel mimicking phantoms in‐vitro and sheep brain samples ex‐vivo. For effective image reconstruction from the data acquired by multi‐angle illumination method, we have utilized a method based on the extraction of maximum intensity. In both cases, multi‐angle illumination has out‐performed the conventional fixed angle illumination technique to improve the overall image quality. Specifically, extraction of the imaging targets located at greater axial depths was possible using this multi‐angle illumination technique.

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Section: Introductionmentioning

confidence: 63%

Randomized multi‐angle illumination for improved linear array photoacoustic computed tomography in brain

Manwar

Lara

Prakash

et al. 2022

Journal of Biophotonics

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“…However, this method results in a bulkier probe and changing the angle of illumination is not practical in clinical settings. Other studies, such as those in [27][28][29][30][31], have also investigated this issue, with probe structures that are simple and suitable for clinical use. However, the adjustment of the angle of illumination was either inflexible (requiring the replacement of probe heads or the rotation of the imaging target) or needed precise calibration to maintain the focal point in the imaging plane.…”

Section: Introductionmentioning

confidence: 99%

Adjustable light illumination for linear array photoacoustic computed tomography

Manwar¹,

Benavides²,

Prakash³

et al. 2023

Photons Plus Ultrasound: Imaging and Sensing 2023

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Photoacoustic computed tomography (PACT) utilizing a linear array ultrasound transducer that can be handheld is popular in clinical translation. However, in linear array PACT, one of the challenges is achieving homogenous light illumination of structures from the surface through deep structures within biological tissue with limited optical energy. A circular or rectangular optical fiber bundle attached to both sides of the elevation plane of the transducer at a fixed angle provides light delivery in linear array PACT, but this configuration does not provide optimum homogenous illumination. Therefore, it is essential to have accessibility to angular adjustment of the optical beam path to allow photons to create different pathways. Existing methods for implementing various beam paths are not flexible or require precise calibration for any changes in the angle of illumination. In this study, we propose a simple and effective adjustable-angle illumination scheme for linear array-based PACT to create different illumination focal points randomly within the imaging plane. This method, based on an adjustable angular illumination technique while acquiring photoacoustic signals, allows the incident photons to interact with the imaging targets for longer periods of time and diffuse further in all directions. We have investigated the effectiveness of the proposed method by imaging photoacoustic targets in biological tissues ex-vivo and demonstrated that deeper structures can be successfully identified.

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Multiangle Long-Axis Lateral Illumination Photoacoustic Imaging to Evaluate Tumor Oxygenation

Cited by 2 publications

References 32 publications

Randomized multi‐angle illumination for improved linear array photoacoustic computed tomography in brain

Randomized multi‐angle illumination for improved linear array photoacoustic computed tomography in brain

Adjustable light illumination for linear array photoacoustic computed tomography

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