Multicenter, double-blind, placebo-controlled trial of terfenadine suspension in the treatment of fall-allergic rhinitis in children

Guill, Margaret F.; Buckley, R. G.; ROCHAJR, W; Kemp, James P.; Sega, Aurelia; Shirley, Lauren; Tinkelman, David G.; SHAATHSCHWEN, Z; Dietrich, K.; Wille, Lucia

doi:10.1016/0091-6749(86)90107-7

Cited by 30 publications

(2 citation statements)

References 5 publications

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“…One report described three cases of preschool age children who developed uncontrollable behavior and hallucinations involving spiders and insects after receiving actifed (Sankey, Nunn, & Sills, 1984), while the second report described three preschool age children with varicella zoster infection who developed visual and auditory hallucinations following the topical application of large amounts of diphenhydramine (Chan & Wallander, 1991). One study of 117 6- to 12-year-old children compared the clinical effectiveness of terfenadine and placebo (Guill et al., 1986). No differences were found between the two groups in adverse reactions or side effects, but the omission of psychomotor tests and of a traditional-antihistamine treated group precludes drawing any conclusion from this report about the implication of antihistamines with regard to sedation and school performance in children.…”

Section: Asthma As a Primary Source Of Neurocognitive Changementioning

confidence: 99%

Are asthmatic children educationally handicapped?

Bender¹

1995

School Psychology Quarterly

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Asthma is a common illness of childhood and may place children at risk for educational difficulties. Some asthmatic children demonstrate neurocognitive impairment or interruption in academic progress as a direct or indirect effect of the disease or its treatment. Contributing factors may include increased school absenteeism, medication side effects, and in severe instances respiratory arrest and hypoxia. However, for most asthmatic children these factors do not result in educational impairment. Neither illness severity or rate of school absence predict achievement levels. Further, several studies have demonstrated that, on average, academic achievement among asthmatic children is no less than that of their peers. Those at greatest risk for difficulty in school adaptation are children with poorly controlled asthma who are isolated from peers and physically inactive. The risks for educational as well as psychosocial impairment in these children is further increased with the co-occurrence of multiple risk factors, including severe illness, poverty, and family dysfunction.

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Section: Asthma As a Primary Source Of Neurocognitive Changementioning

confidence: 99%

Are asthmatic children educationally handicapped?

Bender¹

1995

School Psychology Quarterly

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“…Terfenadine is a non-sedative histamine receptor antagonist [1,2]. There are reports in the literature which have shown the effectiveness of terfenadine in several allergic disorders [3][4][5], and in relieving the bronchospasm provoked by hyperventilation [6], exercise [7], ultrasonically nebulized distilled water [8], and cold air [9] in asthmatic subjects. These reports suggested that the beneficial effects of terfenadine were due to its antihistaminic property.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of terfenadine on mediator release from human blood basophils and eosinophils

Nabe

Agrawal

Sarmiento

et al. 1989

Clin Experimental Allergy

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The effect of terfenadine on histamine release from human basophils and LTC4 production and release from human eosinophils was evaluated. Eosinophils and basophils were obtained by discontinuous gradient centrifugation of the peripheral blood of atopic asthma patients who were off medication. Anti-IgE-induced histamine release from human basophils was significantly inhibited by terfenadine. Maximum inhibition was obtained at 1 x 10(-5) M terfenadine (percentage inhibition = 57.0 +/- 20.1; P less than 0.05). However, only the highest dose of terfenadine used in this study, i.e. 2 x 10(-5) M, significantly inhibited calcium ionophore (A23187)-induced histamine release from human basophils (percentage inhibition = 40.0 +/- 14.6; P less than 0.05), and LTC4 production from human eosinophils (percentage inhibition = 59.8 +/- 9.9; P less than 0.05. These findings demonstrate that terfenadine, in addition to its known antihistamine property, also has an inhibitory effect on chemical mediator release.

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Are terfenadine and astemizole non‐sedative antihistamine compounds? A meta‐analysis

Delargy

1992

Pharmacoepidemiology and Drug

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Objective: To assess the likelihood of astemizole and terfenadine inducing drowsiness compared with placebo in the light of recent reports that these antihistamines are not necessarily drowsiness‐free.Method: Meta‐analysis was used to analyse data obtained from a search of the reports of trials of terfenadine, astemizole and chlorpheniramine. The latter was included as a positive control.Results: Of the 284 trials screened, 229 were unsuitable for detailed analysis for various reasons, including use of concomitant medication, lack of pertinent information and duplicate publication. Fifty five trials contained the necessary details, 18 of these were cross‐over trials and 37 parallel group trials. Our analyses suggest that the design used had an effect on the incidence of drowsiness reported. Both astemizole and terfenadine were no more likely than placebo to induce drowsiness. The Mantel‐Haenszel pooled odds ratio (ORMH) and confidence interval (CI) for terfenadine were ORMH = 1.01; CI = [0.64, 1.57] for the parallel group trials. The astemizole data were too sparse for pooling with largely zero incidence rates. Chlorpheniramine was clearly sedative (ORMH = 4.07; CI = [2.25, 7.36] 95%).In the cross‐over trials, none of the three antihistamines induced more drowsiness than a placebo, thus suggesting that such trials may mask potential subjective adverse effects.Conclusion: Our results are consistent with the hypothesis that astemizole and terfenadine are essentially non‐sedative antihistamine compounds, while chlorpheniramine is sedative. Care should be exercised when evaluating potentially subjective adverse effects and trial design should be considered as a possible confounding factor.

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Multicenter, double-blind, placebo-controlled trial of terfenadine suspension in the treatment of fall-allergic rhinitis in children

Cited by 30 publications

References 5 publications

Are asthmatic children educationally handicapped?

Are asthmatic children educationally handicapped?

Inhibitory effect of terfenadine on mediator release from human blood basophils and eosinophils

Are terfenadine and astemizole non‐sedative antihistamine compounds? A meta‐analysis

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