2023
DOI: 10.1128/spectrum.02547-22
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Multicenter Evaluation of the FilmArray Blood Culture Identification 2 Panel for Pathogen Detection in Bloodstream Infections

Abstract: Rapid molecular diagnosis combining the identification of pathogens and the detection of antibiotic resistance genes from positive blood cultures (BC) can improve the outcome for patients with bloodstream infections. The FilmArray BCID2 panel, an updated version of the original BCID, can detect 11 Gram-positive bacteria, 15 Gram-negative bacteria, 7 fungal pathogens, and 10 antimicrobial resistance genes directly from a positive BC.

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Cited by 19 publications
(13 citation statements)
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“…We observed no false-positive BCID2 results. The high analytic sensitivity and specificity are consistent with the high concordance between BCID2 and culture-based diagnostics in previous studies [8,9]. A systematic review on the performance of the BCID2 panel found only few false-positives in the 10 studies included, mainly S. epidermidis, without further specification [10].…”
Section: Concordance Bcid2 and Conventional Culturesupporting
confidence: 80%
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“…We observed no false-positive BCID2 results. The high analytic sensitivity and specificity are consistent with the high concordance between BCID2 and culture-based diagnostics in previous studies [8,9]. A systematic review on the performance of the BCID2 panel found only few false-positives in the 10 studies included, mainly S. epidermidis, without further specification [10].…”
Section: Concordance Bcid2 and Conventional Culturesupporting
confidence: 80%
“…Thus, in a Norwegian context with predictable and low levels of AMR, rapid genus and species‐specific level identification is of high significance to support relevant changes in empirical antimicrobial treatment in a majority of patients. Several studies have discussed the need for an additional expansion of the panel, including pan‐ Bacteroides and pan‐ Clostridium [8]. We do not consider limitations in the current BCID2 panel to be a significant weakness, when used as a supplement to traditional cultivation‐based methodology.…”
Section: Discussionmentioning
confidence: 99%
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“…However, gram-negative bacteria, including Stenotrophomonas maltophilia and Bacteroides , and gram-positive bacteria, including Clostridium , could be clinically significant pathogens to patients [ 17 ]. Fortunately, the recent upgrade of the BCID2 panel format is expected to overcome the limitations of the current BCID panel by including Bacteroides fragilis and Stenotrophomonas maltophilia as targets among the gram-negative bacteria not included in the BCID panel [ 18 , 19 ]. However, Clostridium , which can still be clinically significant, was not added to the BCID2 panel; accordingly, additional consideration is needed.…”
Section: Discussionmentioning
confidence: 99%
“…Further studies are required to confirm this conclusion including whole-genome sequencing of the CPE strains to determine the clonality. Furthermore, various diagnostic methods are being investigated for the rapid diagnosis of multidrug-resistant organisms, which plays an important role in preventing transmission [ 22 , 23 , 24 , 25 ].…”
Section: Discussionmentioning
confidence: 99%