Multicenter prospective study on device-associated infection rates and bacterial resistance in intensive care units of Venezuela: International Nosocomial Infection Control Consortium (INICC) findings

Empaire, Gabriel D.; Siritt, María Eugenia Guzmán; Rosenthal, Víctor D.; Pérez, F.; Ruiz, Yvis; Díaz, Claudia Olivares; Silvestre, Gabriela Di; Salinas, Evelyn; Orozco, Nelva

doi:10.1093/inthealth/ihw049

Cited by 13 publications

(23 citation statements)

References 30 publications

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“…Our interventions resulted to a significant decrease in CLABSI rates from 15.9/1000DD (2015), to 4.2/1000DD (2016) and then to 1.95/1000DD during the 2017 surveillance period (phase three). The absolute 2017 rate appears to be lower than the majority of the reported published literature [5,8,36,[41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60]. By the beginning of the next period (2016), our efforts resulted to a significant decrease in CLABSI rates from 15.9/1000DD (2015), to 4.2/1000DD (2016) and then to 1.95/1000DD during the 2017 surveillance period (phase three).…”

Section: Discussionmentioning

confidence: 79%

“…By the beginning of the next period (2016), our efforts resulted to a significant decrease in CLABSI rates from 15.9/1000DD (2015), to 4.2/1000DD (2016) and then to 1.95/1000DD during the 2017 surveillance period (phase three). The absolute 2017 rate appears to be lower than the majority of the reported published literature [5,8,[48][49][50][51][52][53][54][55][56][57]36,[58][59][60][41][42][43][44][45][46][47]. By comparing DA-HAI rates between 2015 and 2016 (phases one and two), a strong correlation was found, but there was no significant correlation between the 2016 vs. 2017 period.…”

Section: Discussionmentioning

confidence: 86%

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The effectiveness of a Comprehensive Device Associated Healthcare-Associated Infections Prevention and Control Program: results of a 3-year program in the Republic of Cyprus

Iordanou¹,

Middleton²,

Papathanassoglou³

et al. 2019

Preprint

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Background: Device-associated health care-associated infections (DA-HAIs) are a major threat to patient safety, particularly in the Intensive Care Unit (ICU). The aim of this study was to evaluate the effectiveness of a bundle of infection control measures to reduce DA-HAIs in the ICU of a General Hospital in the Republic of Cyprus, over a three-year period. Methods: We studied 599 ICU patients with length of stay (LOS) for at least 48 hours. Our prospective cohort study was divided into three surveillance phases. VAP, CLABSI, and CAUTI incidence rates, LOS and mortality were calculated before, during and after the infection prevention and control program. Results: There was a statistically significant reduction in the number of DA-HAI events during the surveillance periods, associated with DA-HAIs prevention efforts. In 2015 (prior to program implementation), the baseline DA-HAIs instances were 43: 16 VAP (10.1/1000 Device Days), 21 (15.9/1000DD) CLABSIs and 6 (2.66/1000DD) CAUTIs, (n=198). During the second phase (2016), CLABSIs prevention measures were implemented and the number of infections were 24: 14 VAP (12.21/1000DD), 4 (4.2/1000DD) CLABSIs & 6 (3.22/1000DD) CAUTIs, (n=184). During the third phase (2017), VAP and CAUTI prevention measure were again implemented and the rates were 6: (3 VAP: 12.21/1000DD), 2 (1.95/1000DD) CLABSIs & 1 (0.41/1000DD) CAUTIs, (n=217). There was an overall reduction of 87% in the total number of DA-HAIs instances for the period 01/01/15 to 31/12/17. Conclusions: The significant overall reduction in DA-HAI rates, indicates that a comprehensive infection control program can affect DA-HAI rates.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 86%

The effectiveness of a Comprehensive Device Associated Healthcare-Associated Infections Prevention and Control Program: results of a 3-year program in the Republic of Cyprus

Iordanou¹,

Middleton²,

Papathanassoglou³

et al. 2019

Preprint

View full text Add to dashboard Cite

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“…So, maternal vaginal bacterial flora is the most common source of pathogens that cause EO infections [56]. The rate of morbidity is about ∼1-2 per a thousand of neonatal, however, mortality rate reaches to ∼3 % amongst terms newborns, and ∼16% in very-low-birth-weight (VLBW) babies [56], [57], [58], [59].…”

Section: Types Of Babies' Infections Early-onset (Eo) Infectionsmentioning

confidence: 99%

“…In fact, following an effective and completed infection manage program centered on DA-HAI surveillance has appeared to be successful in several studies conducted in the US, proposing that the rate of DA-HAI can be diminished by as much as 30% [59].…”

Section: Preventing Transmission From the Environmentmentioning

confidence: 99%

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Screening and Prevention of Nosocomial Infections in Neonatal Intensive Care Unit (NICU)

2019

Adv. Environ. Biol

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One of the most causes of patient morbidity and mortality is device-associated healthcare-acquired diseases (DA-HAIs), which is capable of prolonging the length of stay in the intensive care unit (ICU) [7]. Many researches demonstrated that healthcareassociated pathogens repeatedly contaminate the patient's environment. This environment includes both porous surfaces ex: towels and nonporous, hard surfaces ex: table [8]. Whereas, these contaminated surfaces can transmit of pathogens by directly way by Abstract Infants in neonatal intensive care units (NICUs) are usually immunocompromised. So, healthcare-associated infections (HAIs), also known as, nosocomial infections, consider a severe issue for infants in neonatal intensive care units (NICUs). HAIs are described as onset more than 48 hours after hospital admission. In fact, it is responsible for the increase of mortality, morbidity and the duration of stay in the hospital. The rate of HAIs in NICU is range from 6% to 50% per admission. However, this rate rises by 3 to 20-fold in developing countries as contrasted to developed countries. Also, about 2.9 million newborns die yearly during the initial 28 days of their life. Importantly, the environment that surrounds the patients is full by equipment for organ support and monitoring e.g., ventilator, monitors, extracorporeal life support machines. Moreover, the bacteria infectious may come from different resources (e.g., people in the hospital, healthcare' hands, on equipment or surfaces). In fact, HAIs regularly rise as a result of the formation of biofilms at the surfaces of these medical devices. The most gram-positive bacteria that because HAIs are Group B Streptococci, Listeria, Staphylococcus aureus, Methicillin-resistant S. aureus (MRSA). As for gram-negative bacteria such as Escherichia coli, Enterobacter, Klebsiella, Pseudomonas, Serratia, Salmonella…etc., some of these bacteria are resistance for most of the antibiotics. World Health Organization (WHO) put many infection control techniques that may help to reduce the nosocomial infections. Therefore, this review aims to highlight and give brief information about the problem of healthcare-associated infections in NICU and the methods of environmental decontamination in hospitals.

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Multinational Prospective Cohort Study of Mortality Risk Factors in 198 ICUs of 12 Latin American Countries over 24 Years: The Effects of Healthcare-Associated Infections

Rosenthal

Yin

Valderrama-Beltrán

et al. 2022

J Epidemiol Glob Health

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Background The International Nosocomial Infection Control Consortium (INICC) has found a high ICU mortality rate in Latin America. Methods A prospective cohort study in 198 ICUs of 96 hospitals in 46 cities in 12 Latin American countries to identify mortality risk factors (RF), and data were analyzed using multiple logistic regression. Results Between 07/01/1998 and 02/12/2022, 71,685 patients, followed during 652,167 patient-days, acquired 4700 HAIs, and 10,890 died. We prospectively collected data of 16 variables. Following 11 independent mortality RFs were identified in multiple logistic regression: ventilator-associated pneumonia (VAP) acquisition (adjusted odds ratio [aOR] = 1.17; 95% CI: 1.06–1.30; p < 0.0001); catheter-associated urinary tract infection (CAUTI) acquisition (aOR = 1.34; 95% CI: 1.15–1.56; p < 0.0001); older age, rising risk 2% yearly (aOR = 1.02; 95% CI: 1.01–1.02; p < 0.0001); longer indwelling central line(CL)-days, rising risk 3% daily (aOR = 1.03; 95% CI: 1.02–1.03; p < 0.0001); longer indwelling urinary catheter(UC)-days, rising risk 1% daily (aOR = 1.01; 95% CI: 1.01–1.26; p < 0.0001); higher mechanical ventilation (MV) (aOR = 6.47; 95% CI: 5.96–7.03; p < 0.0001) and urinary catheter-utilization ratio (aOR = 1.19; 95% CI: 1.11–1.27; p < 0.0001); lower-middle level income country (aOR = 2.94; 95% CI: 2.10–4.12; p < 0.0001); private (aOR = 1.50; 95% CI: 1.27–1.77; p < 0.0001) or public hospital (aOR = 1.47; 95% CI: 1.24–1.74; p < 0.0001) compared with university hospitals; medical hospitalization instead of surgical (aOR = 1.67; 95% CI: 1.59–1.75; p < 0.0001); neurologic ICU (aOR = 4.48; 95% CI: 2.68–7.50; p < 0.0001); adult oncology ICU (aOR = 3.48; 95% CI: 2.14–5.65; p < 0.0001); and others. Conclusion Some of the identified mortality RFs are unlikely to change, such as the income level of the country, facility ownership, hospitalization type, ICU type, and age. But some of the mortality RFs we found can be changed, and efforts should be made to reduce CL-days, UC-days, MV-utilization ratio, UC-utilization ratio, and lower VAPs and CAUTI rates.

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Multicenter prospective study on device-associated infection rates and bacterial resistance in intensive care units of Venezuela: International Nosocomial Infection Control Consortium (INICC) findings

Abstract: DA-HAI rates in our ICUs are higher than CDC/NSHN's and similar to or lower than INICC international rates.

Cited by 13 publications

References 30 publications

The effectiveness of a Comprehensive Device Associated Healthcare-Associated Infections Prevention and Control Program: results of a 3-year program in the Republic of Cyprus

The effectiveness of a Comprehensive Device Associated Healthcare-Associated Infections Prevention and Control Program: results of a 3-year program in the Republic of Cyprus

Screening and Prevention of Nosocomial Infections in Neonatal Intensive Care Unit (NICU)

Multinational Prospective Cohort Study of Mortality Risk Factors in 198 ICUs of 12 Latin American Countries over 24 Years: The Effects of Healthcare-Associated Infections

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