2013
DOI: 10.1515/cclm-2013-0410
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Multicenter reference intervals studies: a promising perspective for the future?

Abstract: Up to now the establishment of reference limits has been based on the recommendations of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC-LM) which give greater place to determining reference intervals (RIs) in each laboratory [ 1 ]. In fact, the situation is complex: regulations (e.g., European Directive 98/79/EC [ 2 ] and the new revised version pending approval) require that manufacturers mention RIs in the package inserts (for all countries). Clinical laboratories are respon… Show more

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Cited by 3 publications
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“…These differences make it difficult to obtain universally applicable reference intervals, even though the applied methodology is traceable to reference measurement systems [46], [47]. As producing reference ranges is an expensive task for an individual laboratory, one possible solution is to establish reference ranges for a homogeneous population by involving all the laboratories measuring the certain analyte with the same method [47]. Siest et al emphasized that the boundaries between healthy and pathological conditions are not clear-cut, and reference intervals or cut-off values should be established to expedite clinical decision making [48].…”
Section: Discussionmentioning
confidence: 99%
“…These differences make it difficult to obtain universally applicable reference intervals, even though the applied methodology is traceable to reference measurement systems [46], [47]. As producing reference ranges is an expensive task for an individual laboratory, one possible solution is to establish reference ranges for a homogeneous population by involving all the laboratories measuring the certain analyte with the same method [47]. Siest et al emphasized that the boundaries between healthy and pathological conditions are not clear-cut, and reference intervals or cut-off values should be established to expedite clinical decision making [48].…”
Section: Discussionmentioning
confidence: 99%