Multicenter study of bitolterol and isoproterenol nebulizer solutions in nonsteroid-using patients

Sympathomimetics have become a mainstay of the treatment of acute asthma. Aerosolization of sympathomimetics provides as great or greater bronchodilation in acute severe asthma with fewer systemic effects than parenteral therapy. Despite the broncho-selectivity achieved with this route of administration, cardiostimulation remains the major, dose-limiting factor in the safe use of sustained, high-dose therapy with these agents. This article reviews the pharmacology, adverse effects toxicities of selected beta agonists, as well as clinical studies relevant to the question posed in the title. Although the ideal study to answer this question has not yet been performed, the authors feel that available evidence supports the preferential use of selective beta2 agonists in patients with acute, severe asthma who will require high doses of beta agonists.

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Multicenter study of bitolterol and isoproterenol nebulizer solutions in nonsteroid-using patients

Cited by 5 publications

References 27 publications

Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults

Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults

Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults

Sympathomimetics for Acute Severe Asthma: Should Only Beta₂-Selective Agonists Be Used?

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Multicenter study of bitolterol and isoproterenol nebulizer solutions in nonsteroid-using patients

Cited by 5 publications

References 27 publications

Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults

Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults

Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults

Sympathomimetics for Acute Severe Asthma: Should Only Beta2-Selective Agonists Be Used?

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Resources

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Sympathomimetics for Acute Severe Asthma: Should Only Beta₂-Selective Agonists Be Used?