Multicenter study on invasive Streptococcus pyogenes infections in children in Argentina

Cancellara, Aldo; Melonari, Pablo; Firpo, María; Monaco, Andrea Lo; Ezcurra, Gustavo; Ruizf, Lía; Aletti, Alicia; Gregorio, Gabriela; Gaiano, Alejandra; Aird, Alberto; Bellone, Luciana; Calvari, Miriam; Torregrosa, Carolina; Morinigo, Sandra; Vozzan, María L; Tonetto, Ivana; Flynn, Luis Pedro; Bidone, Nancy; Russ, Carlota; Ellis, Anna

doi:10.5546/aap.2016.eng.199

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…ISPDs have a broad and evolving clinical spectrum. Previous reports identified skin as a potential source for main trigger that leads to clinical manifestation of bacteremia or sepsis [6, 7], which were in accordance with our findings that 31.8% of the patients had skin or soft tissue infections as predisposing factors, indicating that pediatricians and emergency physicians must be aware of this possibility when treat skin or soft tissue infection. Zachariadou et al [8] reported that varicella and streptococcal pharyngotonsillitis was the main predisposing factors in children, which was not supported in the present study.…”

Section: Discussionsupporting

confidence: 92%

A multi-center clinical investigation on invasive Streptococcus pyogenes infection in China, 2010–2017

Chen

et al. 2019

BMC Pediatr

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Background Invasive S. pyogenes diseases are uncommon, serious infections with high case fatality rates (CFR). There are few publications on this subject in the field of pediatrics. This study aimed at characterizing clinical and laboratory aspects of this disease in Chinese children. Patients and methods A retrospective study was conducted and pediatric in-patients with S. pyogenes infection identified by cultures from normally sterile sites were included, who were diagnosed and treated in 9 tertiary hospitals during 2010–2017. Results A total of 66 cases were identified, in which 37 (56.1%) were male. The median age of these patients, including 11 neonates, was 3.0 y. Fifty-nine (89.4%) isolates were determined from blood. Fever was the major symptom (60/66, 90.9%) and sepsis was the most frequent presentation (64/66, 97.0%, including 42.4% with skin or soft tissue infections and 25.8% with pneumonia. The mean duration of the chief complaint was (3.8 ± 3.2) d. Only 18 (27.3%) patients had been given antibiotics prior to the hospitalization. Among all patients, 15 (22.7%) developed streptococcal toxin shock syndrome (STSS). No S. pyogenes strain was resistant to penicillin, ceftriaxone, or vancomycin, while 88.9% (56/63) and 81.4% (48/59) of the tested isolates were resistant to clindamycin and erythromycin respectively. Most of the patients were treated with β-lactams antibiotics and 36.4% had been treated with meropenem or imipenem. Thirteen (19.7%) cases died from infection, in which 9 (13.6%) had complication with STSS. Conclusions Invasive S. pyogenes infections often developed from skin or soft tissue infection and STSS was the main cause of death in Chinese children. Ongoing surveillance is required to gain a greater understanding of this disease.

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Section: Discussionsupporting

confidence: 92%

A multi-center clinical investigation on invasive Streptococcus pyogenes infection in China, 2010–2017

Chen

et al. 2019

BMC Pediatr

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Analysis of 11 Cases of Neonatal Invasive Streptococcus pyogenes Infection

Xie

Chen

et al. 2020

Journal of Pediatric Infectious Diseases

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Objective This study aimed to improve the understanding of clinical characteristics of neonatal invasive Streptococcus pyogenes infection (iSPI). Methods A retrospective study was performed to analyze the clinical and laboratory aspects of culture-confirmed neonatal iSPI cases during 2010 to 2017. Results Eleven cases of neonatal iSPI were confirmed. The ages ranged from 2 hours to 26 days. Ten cases had positive blood culture results and one had positive cerebrospinal fluid culture for S. pyogenes. Seven patients had fever and seven had identified focal infection, including six skin and soft tissue infections and one case of pneumonia. All of the S. pyogenes strains were sensitive to penicillin, cefotaxime, and vancomycin, and nine were resistant to clindamycin and erythromycin. Six patients received penicillin or cephalosporin monotherapy. Three patients received meropenem plus vancomycin initially, and then two of them were switched to penicillin and one to vancomycin after pathogen identification. Two cases were treated with vancomycin monotherapy. All cases were discharged after being cured or showing improvement. Conclusion Skin and soft tissue infection is a common manifestation of neonatal iSPI. Streptococcus pyogenes strains are highly sensitive to β-lactams, which should be used as the first-choice treatment.

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Clinical and Laboratory Features of Invasive Group A Streptococcal Infections: 8 Years Experience

Şahin¹,

Yüksel²,

Öncel³

et al. 2021

Turk Arch Pediatrics

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Multicenter study on invasive Streptococcus pyogenes infections in children in Argentina

Cited by 3 publications

References 22 publications

A multi-center clinical investigation on invasive Streptococcus pyogenes infection in China, 2010–2017

A multi-center clinical investigation on invasive Streptococcus pyogenes infection in China, 2010–2017

Analysis of 11 Cases of Neonatal Invasive Streptococcus pyogenes Infection

Clinical and Laboratory Features of Invasive Group A Streptococcal Infections: 8 Years Experience

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