Multicenter Survey with a Systematic Overview of Acute-Onset Endophthalmitis after Transconjunctival Microincision Vitrectomy Surgery

Oshima, Yusuke; Kadonosono, Kazuaki; Yamaji, Hidetaka; Inoue, Makoto; Yoshida, Munenori; Kimura, Hideya; Ohji, Masahito; Shiraga, Fumio; Hamasaki, Toshimitsu

doi:10.1016/j.ajo.2010.06.002

Cited by 72 publications

(83 citation statements)

References 41 publications

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“…The reported incidence rate of acute-onset endophthalmitis after 25-gauge vitrectomy is 0.030–0.070% [23,24,25]. Although it is difficult to compare the data obtained with different types of treatment, these rates appear to be similar to those of postinjection endophthalmitis reported from previous and current studies.…”

Section: Discussionsupporting

confidence: 63%

Evaluation of the Incidence of Endophthalmitis after Intravitreal Injection of Anti-Vascular Endothelial Growth Factor

et al. 2011

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Aims: To report the incidence of infectious and noninfectious endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor (VEGF) from a multicenter clinical trial in Japan. Methods: A retrospective multicenter review of the data of patients who received intravitreal anti-VEGF injections between January 2007 and March 2011 was undertaken. Cases with the clinical diagnosis of endophthalmitis resulting from intravitreal injection were identified and reviewed. Results: A total of 5,236 intravitreal anti-VEGF injections (1,209 intravitreal injections of bevacizumab, 3,827 injections of ranibizumab, and 200 injections of pegaptanib sodium) had been administered. Five patients (0.095%), all of whom had received bevacizumab, were diagnosed as having endophthalmitis after the intravitreal injection. All patients visited the institutes for re-examination within 1–2 days after the injection. Among the 5 patients, 2 (0.038%) were culture positive for Streptococcus oralis and Enterococcus faecalis, respectively. The remaining 3 eyes (0.057%) developed presumed noninfectious endophthalmitis. Conclusion: Although endophthalmitis is a rare complication associated with intravitreal injection, in this series intravitreal anti-VEGF injection caused infectious or noninfectious endophthalmitis at a relatively high frequency. Further investigations are needed to consider an appropriate injection protocol for minimizing the incidence rates of endophthalmitis, and to assess the optimal treatment protocol for intravitreal injection-related endophthalmitis although it was difficult to differentiate these two entities.

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Section: Discussionsupporting

confidence: 63%

Evaluation of the Incidence of Endophthalmitis after Intravitreal Injection of Anti-Vascular Endothelial Growth Factor

et al. 2011

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“…7 The endophthalmitis rate after PPV is reported to be 0.03% to 0.054%. 8,9 There was no difference in the rate of endophthalmitis between traditional 20-gauge and sutureless transconjunctival vitrectomy, 7-11 except in a study by Kunimoto and Kaiser, 12 who found a 12-fold increased risk in 25-gauge vitrectomy over 20-gauge vitrectomy in 8601 eyes.…”

Section: Discussionmentioning

confidence: 87%

Incidence of postoperative endophthalmitis from 1990 to 2009 using povidone–iodine but no intracameral antibiotics at a single academic institution

Nentwich¹,

Ta²,

Kreutzer³

et al. 2015

Journal of Cataract and Refractive Surgery

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“…In the era of microincision vitrectomy surgery, angled incision is preferred to create the wound for trocar placement [12,13] because it improves wound sealing and thus prevents postoperative complications such as hypotony and endophthalmitis [14][15][16]. Even with this technique, however, the sealing is not always complete [17] and wound-related complications can still occur.…”

Section: Wound Constructionmentioning

confidence: 98%

Idiopathic Macular Hole

Oh¹

2014

Developments in Ophthalmology

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Idiopathic macular hole is a disease that arises from adhesion in the vitreomacular interface and can theoretically be treated by vitrectomy surgery. Surgical techniques include removal of the vitreous with or without simultaneous peeling of the internal limiting membrane (ILM), fluid-air exchange, and gas tamponade. Since the advent of microincision vitrectomy surgery, macular hole surgery has been performed with minimal invasiveness, and significant visual improvement is a common outcome. This chapter describes the pathology of this disease, including presurgical evaluation using optical coherence tomography (OCT), and then shows the fundamental techniques required for the surgery. Also important is the understanding of the postsurgical 'healing' process of the disease, which may confirm the fact that the subjective improvement is closely related to the retinal imaging obtained by OCT. More recent advances are the inverted ILM peeling technique for larger macular holes and 27-gauge vitrectomy that can potentially minimize the surgical invasiveness mainly by smaller wound construction and the reduced volume of irrigation during surgery.

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Multicenter Survey with a Systematic Overview of Acute-Onset Endophthalmitis after Transconjunctival Microincision Vitrectomy Surgery

Cited by 72 publications

References 41 publications

Evaluation of the Incidence of Endophthalmitis after Intravitreal Injection of Anti-Vascular Endothelial Growth Factor

Evaluation of the Incidence of Endophthalmitis after Intravitreal Injection of Anti-Vascular Endothelial Growth Factor

Incidence of postoperative endophthalmitis from 1990 to 2009 using povidone–iodine but no intracameral antibiotics at a single academic institution

Idiopathic Macular Hole

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