Multicenter trial of propranolol in angina pectoris

Grant, Richard H.; Keelan, P; Kernohan, Robert J.; Leonard, John C.; Nancekievill, Leslie; Sinclair, K.

doi:10.1016/0002-9149(66)90054-3

Cited by 135 publications

(19 citation statements)

References 13 publications

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“…Since most of the AXe washed out of cardiac tissue is excreted in one passage by the lungs (14,36), recirculation of the remainder is so minimal that isotope does not appear in the chest wall in sufficient amounts to alter myocardial wash-out curves. 6 The scintillation camera allows quantitative measurements of isotope removal from many areas of 8 In the studies to date, spillage of isotope into the aorta with obscuration of myocardial washout of 'Xe by accumulation of the tracer in overlying chest wall has not been a problem for two reasons: (a) Isotope movement down the aorta can be detected during replay of the magnetic tape on the oscilloscope. (b) Dilution of AXe (10 mCi) injected into the root of the aorta by aortic blood flow was so great that the count rates recorded by crystals overlying the chest wall were not significantly increased above background.…”

Section: Regional Myocardial Perfusion In Man 971mentioning

confidence: 99%

“…Application of newer therapeutic interventions (1)(2)(3)(4)(5)(6) to the extensive population of patients with coronary atherosclerosis (7)(8) has been retarded by the absence of techniques to quantitatively assess regional myocardial blood flow in intact man. Coronary cineradiography is widely used diagnostically to localize constrictions or occlusions of large or medium-sized coronary vessels (9).…”

Section: Introductionmentioning

confidence: 99%

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Measurement of Regional Myocardial Perfusion in Man with 133Xenon and a Scintillation Camera

Cannon¹,

Dell²,

Dwyer³

1972

J. Clin. Invest.

120

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A B S T R A C T A method was devised to quantitate regional capillary perfusion in the human heart by measuring the clearance constants (k) of Xenon-133 washout from multiple areas of the myocardium with a multiple-crystal scintillation camera. In 17 subjects, "'Xe was injected into the right or left coronary artery or both and counts per second (cps) were recorded simultaneously on magnetic tape from each of 294 scintillation crystals viewing the precordium through a multichannel collimator. Data were processed by a digital computer. Crystals detecting the myocardial washout of 'Xe were distinguished from those monitoring pulmonary excretion by positioning radioactive markers at the cardiac margins, and by a computer printout of the peak cps recorded by each crystal and its time after isotope injection into the coronary artery. The slopes of the initial segment of the multiple "'Xe curves obtained in each study were calculated by the method of least squares using a monoexponential model. Myocardial blood flow rates in the cardiac regions viewed by the individual crystals were calculated (assuming a blood to myocardium partition coefficient of 0.72) along with the SD of every flow measurement. The pattern of myocardial perfusion rates so obtained was superimposed over a tracing of the subject's coronary arteriogram. Scintiphotographs showing the arrival and washout of isotope from various regions of myocardium and the area of tissue perfused by each coronary artery were obtained by replaying the data tape on an oscilloscope. Significant regional variations in local myocardial perfusion rates were observed in hearts with normal coronary arteries.

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Section: Regional Myocardial Perfusion In Man 971mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Measurement of Regional Myocardial Perfusion in Man with 133Xenon and a Scintillation Camera

Cannon¹,

Dell²,

Dwyer³

1972

J. Clin. Invest.

120

View full text Add to dashboard Cite

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“…These results are further evidence that fl-adrenoceptor blocking drugs with sympathomimetic activity are inferior to a compound without such activity in the treatment of hyperthyroid tachycardia. (Hamer & Sowton, 1966;Grant et al, 1966;Birkett & Chamberlain, 1966;Wilson, Brooke, Lloyd & Robinson, 1969). Propranolol has 3-adrenoceptor blocking and local anaesthetic properties either of which might be responsible for its action.…”

Section: Pmentioning

confidence: 99%

PROCEEDINGS OF THE BRITISH PHARMACOLOGICAL SOCIETY, 8TH‐9TH‐10TH July, 1970

1970

British J Pharmacology

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“…The beneficial effect of P-adrenoceptor antagonists in the treatment of angina pectoris is well described (Battock et al, 1969;Gianelly et al, 1967;Grantz et al, 1966;Wolfson & Gorlin, 1969). Furthermore, in addition, a favourable influence on morbidity and mortality following acute myocardial infarction has been reported in controlled long-term studies (Multicentre International Study, 1975;Baber et al, 1980;The Norwegian Multicenter Study Group, 1981).…”

Section: Introductionmentioning

confidence: 96%

The effect of pindolol on myocardial blood flow, metabolism and function during rest and pacing in patients with coronary heart disease.

Küpper¹,

Cw²,

Bleifeld³

1982

Brit J Clinical Pharma

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1 The study was designed to elucidate further the mechanism by which P-adrenoceptor antagonism with pindolol relieves the symptoms of angina pectoris in patients with coronary heart disease. 2 Pindolol administration was associated with an elevated threshold for angina pectoris and improved myocardial lactate metabolism during supraventricular pacing. 3 This beneficial effect of pindolol was independent of changes in myocardial blood flow and was not mediated by haemodynamic effects. 4 The results suggest that in angina pectoris, in addition to the recognized beneficial effects of ,B-adrenoceptor blockade, the actions of pindolol also result from, as yet, poorly described phenomena such as redistribution of myocardial blood flow or metabolic effects.

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Multicenter trial of propranolol in angina pectoris

Cited by 135 publications

References 13 publications

Measurement of Regional Myocardial Perfusion in Man with 133Xenon and a Scintillation Camera

Measurement of Regional Myocardial Perfusion in Man with 133Xenon and a Scintillation Camera

PROCEEDINGS OF THE BRITISH PHARMACOLOGICAL SOCIETY, 8TH‐9TH‐10TH July, 1970

The effect of pindolol on myocardial blood flow, metabolism and function during rest and pacing in patients with coronary heart disease.

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