Multicentre, cross-cultural, population-based, case–control study of physical activity as risk factor for amyotrophic lateral sclerosis

Visser, Anne E.; Rooney, James; D’Ovidio, Fabrizio; Westeneng, Henk‐Jan; Vermeulen, Roel; Beghi, Ettore; Chiò, Adriano; Logroscino, Giancarlo; Hardiman, Orla; Veldink, Jan H.; Berg, Leonard H van den

doi:10.1136/jnnp-2017-317724

Cited by 49 publications

(41 citation statements)

References 39 publications

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“…The literature on environmental exposures includes a large number of studies, mainly focused on trauma,8 nutritional intake,9 physical activity,10 hormones,11 drug consumption,12 holding specific occupations,13 such as construction workers,14 soccer and football players,15 veterinarians and hairdressers,16 power-production plant operators,17 armed forces,18 occupations that imply direct contact with public,19 and job-related industrial and agricultural chemical exposures, such as pesticides, solvents, heavy metals and low-frequency magnetic fields 20–22. In general, several methodological factors decreased the likelihood of identifying established risk factors for ALS, such as inconsistency of findings, difficult exposure assessment, insufficient statistical power and selection bias 13 20 23…”

Section: Introductionmentioning

confidence: 99%

Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study

D’Ovidio

Rooney

Visser

et al. 2018

J Neurol Neurosurg Psychiatry

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Section: Introductionmentioning

confidence: 99%

Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study

D’Ovidio

Rooney

Visser

et al. 2018

J Neurol Neurosurg Psychiatry

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“…The eOR per pack-year by copyright. 14 (11) 28 (11) 29 (14) 71 (10) 153 (8.3) 50 to <60 260 (18) 555 (21) 31 (19) 56 (17) 26 (21) 23 (22) 31 (19) 31 (24) 37 (15) 45 (21) 135 (19) 400 (22) 60 to <70 (20) 377 (14) 33 (20) 35 (11) 27 (22) 30 2931 (19) 19 4546 (18) 37 (17) 150 (21) 256 (14) Intensity, median (cig/day) † 138 (12) 169 (14) 0.87 (0.66 to 1.14)…”

Section: Resultsmentioning

confidence: 99%

“…To explore possible residual confounding from educational level, we performed the same analyses on a post-hoc matched case-control set. 17 Matching was done at an individual level for sex, age, centre and educational level, and conditional logistic regression modelling was applied, adjusted for alcohol drinking status.…”

Section: Methodsmentioning

confidence: 99%

Effect modification of the association between total cigarette smoking and ALS risk by intensity, duration and time-since-quitting: Euro-MOTOR

Peters

Visser

D’Ovidio

et al. 2019

J Neurol Neurosurg Psychiatry

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BackgroundWe investigated the association between cigarette smoking and risk of amyotrophic lateral sclerosis (ALS) in a pooled analysis of population-based case–control studies and explored the independent effects of intensity, duration and time-since-quitting.MethodsALS cases and controls, matched by age, sex and region, were recruited in the Netherlands, Italy and Ireland (*Euro-MOTOR project). Demographics and detailed lifetime smoking histories were collected through questionnaires. Effects of smoking status, intensity (cigarettes/day), duration (years), pack-years and time-since-quitting (years) on ALS risk were estimated using logistic regression models, adjusting for age, sex, alcohol, education and centre. We further investigated effect modification of the linear effects of pack-years by intensity, duration and time-since-quitting using excess OR (eOR) models.ResultsAnalyses were performed on 1410 cases and 2616 controls. Pack-years were positively associated with ALS risk; OR=1.26 (95% CI: 1.03 to 1.54) for the highest quartile compared with never smokers. This association appeared to be predominantly driven by smoking duration (ptrend=0.001) rather than intensity (ptrend=0.86), although the trend for duration disappeared after adjustment for time-since-quitting. Time-since-quitting was inversely related to ALS (ptrend<0.0001). The eOR decreased with time-since-quitting smoking, until about 10 years prior to disease onset. High intensity smoking with shorter duration appeared more deleterious than lower intensity for a longer duration.ConclusionsOur findings provide further support for the association between smoking and ALS. Pack-years alone may be insufficient to capture effects of different smoking patterns. Time-since-quitting appeared to be an important factor, suggesting that smoking may be an early disease trigger.

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“…Still, exogenous factors may trigger or hasten motoneuronal damage. The peculiarity of ALS degeneration turned the attention to environmental exposure which may exert high stress on motor neurons, such as physical activity, trauma and smoking [ 292 , 293 , 294 , 295 ]. The relationship between metabolism, diet and microbiota received proper attention only in the last few years, but evolution in this new field may bridge some of the unresolved gaps in disease pathogenesis ( Table 3 ).…”

Section: Roles Of Diet and Microbiota In Neurodegenerative Diseasementioning

confidence: 99%

Diet, Microbiota and Brain Health: Unraveling the Network Intersecting Metabolism and Neurodegeneration

Gentile

Doneddu

Riva

et al. 2020

IJMS

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Increasing evidence gives support for the idea that extra-neuronal factors may affect brain physiology and its predisposition to neurodegenerative diseases. Epidemiological and experimental studies show that nutrition and metabolic disorders such as obesity and type 2 diabetes increase the risk of Alzheimer’s and Parkinson’s diseases after midlife, while the relationship with amyotrophic lateral sclerosis is uncertain, but suggests a protective effect of features of metabolic syndrome. The microbiota has recently emerged as a novel factor engaging strong interactions with neurons and glia, deeply affecting their function and behavior in these diseases. In particular, recent evidence suggested that gut microbes are involved in the seeding of prion-like proteins and their spreading to the central nervous system. Here, we present a comprehensive review of the impact of metabolism, diet and microbiota in neurodegeneration, by affecting simultaneously several aspects of health regarding energy metabolism, immune system and neuronal function. Advancing technologies may allow researchers in the future to improve investigations in these fields, allowing the buildup of population-based preventive interventions and development of targeted therapeutics to halt progressive neurologic disability.

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Multicentre, cross-cultural, population-based, case–control study of physical activity as risk factor for amyotrophic lateral sclerosis

Abstract: We provide new class I evidence for a positive association between PA and risk of ALS in a large multicentre study using harmonised methodology to objectively quantify PA levels, with some suggestions for population differences.

Cited by 49 publications

References 39 publications

Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study

Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study

Effect modification of the association between total cigarette smoking and ALS risk by intensity, duration and time-since-quitting: Euro-MOTOR

Diet, Microbiota and Brain Health: Unraveling the Network Intersecting Metabolism and Neurodegeneration

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