Multicentre study on the appropriateness of surgical antibiotic prophylaxis

Preoperative antibiotic prophylaxis practice and guideline adherence in Jordan: a multi-centre study in Jordanian hospitals

“…An Indian study reported that antibiotics were administered for as long as 14 days and only 1% to 8% of surgeons who prescribed antibiotics in surgical procedures stopped prophylaxis after 24 hours [16]. Extended prophylaxis has been shown to be of no benefit [2,11,17], and is potentially harmful [2,18] due to the development of drug toxicity, super-infections [2], and bacterial resistance [2,6].…”

“…Ceftriaxone and cefuroxime were the preferred antibiotics used for SAP [16]. In another study performed in Eastern France, among 117 patients who received inappropriate SAP, 95.7% received a broad-spectrum antibiotic regimen [11]. This excessive use of broad-spectrum antibiotics for prophylaxis increases the risk for resistance [2,4,19], causes more adverse events [19], and increases healthcare costs [2,19].…”

“…The appropriate choice of antimicrobial agents, dosage regimen, timing, duration, and route of administration must be evidence based. Inappropriate use of antibiotic prophylaxis, for example, over-consumption or inappropriate timing [9], have been shown to increase the risk of adverse drug reactions [10], hospital costs, emergence of resistant strains of microorganisms, and super-infections [10,11]. Several studies have reported overuse and/or misuse of preoperative antibiotics in various countries [2,3,6,8,10].…”

Evaluation of adherence to surgical prophylaxis guidelines and expenditure on antimicrobial agents used for surgical prophylaxis

“…13,22 Also most of studies states that extended prophylaxis beyond 24 hours has been shown to be of no benefit. 23,24 Also according to a study by Ram GRV et al 16 approximately 30-50% of antibiotics use in hospital practice is now for surgical prophylaxis, however between 30% and 90% of this prophylaxis is inappropriate. Therefore this study decided to calculate cost expenditure over antimicrobial agents (AMA) used for surgical prophylaxis in study departments and excess expenditure on antimicrobial agents used for surgical prophylaxis because of inappropriateness or non-adherence with standard guidelines for surgical prophylaxis.…”

Impact of Different Prophylactic Antibiotic Regimen on Clinical Outcome of Coronary Artery Bypass Graft Surgery

“…Surgery site infection (SSI) is the second most common cause of nosocomial infections and is the most common cause of death after surgery (1,2). Although surgeons follow a certain protocol for antibiotic therapy after open heart surgeries, due to the potentially hazardous post cardiac surgery infections, the duration and type of prophylactic antibiotic remains a controversial challenge (3,4).…”