Multicentric Amyloid Containing Cutaneous Trabecular Carcinoma

Abstract

Light and electron microscopic study of a cutaneous, trabecular carcinoma (Toker 1972) showed the tumor to be amyloid producing. This case was also multicentric and had metastasized only to the liver.

Malignant Merkel Cell Neoplasm of the Eyelid

“…5 Although some tumors appear to grow slowly, others have grown rapid¬ ly and metastasized early and widely. Histologically, most tumors, regardless of site, are composed of smallto medium-sized cells with illdefined borders and moderate amounts of cytoplasm.…”

Synchronous onset of multiple cutaneous neuroendocrine (Merkel cell) carcinomas localized to the scalp

“…The tumors primarily arise in sun‐exposed skin with approximately 50% of tumors occurring in the head and neck region, and 40% arising on the upper or lower extremities 1,16 . The majority of MCCs are solitary; however, there are a few case reports of multiple cutaneous lesions developing either in the local region or at distant sites during the course of the disease 6,8–15 . An even more uncommon presentation, is when multiple tumors arise synchronously at onset; therefore, metastases from a visceral neuroendocrine carcinoma must be excluded 6–8 .…”

“…multiple sites, [6][7][8] or who subsequently developed multifocal cutaneous tumors during the course of their disease. 6,[8][9][10][11][12][13][14][15] We report a case of a 59-year-old white male who presented with abrupt onset of multiple small bluish papules on his frontal scalp. On low power, the tumor had the overall histological silhouette of a nodular basal cell carcinoma (BCC).…”

“…The tumor is typified clinically as a solitary, rapidly enlarging, non‐ulcerated pink nodule or plaque that arises in middle‐aged patients on sun‐damaged skin. There are only isolated case reports of patients who have presented at the onset with multiple cutaneous tumors either locally or at multiple sites, 6–8 or who subsequently developed multifocal cutaneous tumors during the course of their disease 6,8–15 . We report a case of a 59‐year‐old white male who presented with abrupt onset of multiple small bluish papules on his frontal scalp.…”

Small‐Cell Neuroepithelial Tumor of Skin: A Merkel‐Cell Neoplasm?

“…Nuclei are basophilic and cell cytoplasm is usually scant. Amyloid has been found extra‐ and intracellularly but usually is not present 19 . Ultrastructurally, a distinct feature is the presence of membrane‐bound, dense‐core neurosecretory granules in the cytoplasm.…”