Multicentric and diffuse recurrences of meningiomas

Maiuri, Francesco; Mariniello, Giuseppe; Peca, Carmela; Guadagno, Elia; Corvino, Sergio; d'Avanzo, Stefania; De, Marialaura Del Basso

doi:10.1080/02688697.2020.1754335

Cited by 19 publications

(34 citation statements)

References 55 publications

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“…When compared to the findings of meningiomas which showed localizedperipheral recurrences, only the higher rates of flat-shaped tumors (p = 0.0008) and tumors with Ki67-Li ≥4% (p = 0.037) were significant [28].…”

Section: Data Of the Personal Seriesmentioning

confidence: 76%

“…When compared to patients with localized-peripheral recurrences, those with multicentric-diffuse recurrences showed significantly higher number of reoperations (p = 0.0034), lower rate of gross total resection (p = 0.00001) and higher but not significant rate of cases with progression of the WHO grade (p = 0.09) [28].…”

Section: Data Of the Personal Seriesmentioning

confidence: 90%

“…According to their topography on the post-contrast magnetic resonance imaging (MRI) and surgical findings, the recurrences of meningiomas may be classified in 4 types [28]:…”

Section: Classification Of the Recurrencesmentioning

confidence: 99%

“…Thirty-three patients with multicentric-diffuse recurrences of meningiomas are included in our series [28] (Tables 1-3 and Figures 1-3). They are 22 females (67%) and 11 males (33%), with a median age of 52 years.…”

Section: Data Of the Personal Seriesmentioning

confidence: 99%

“…This carries several diagnostic and therapeutic implications. However, all published studies consider the overall recurrences, with no focusing on their topography and extension, which were first discussed only in our recent report [28].…”

Section: Introductionmentioning

confidence: 99%

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Topographic Distribution of Intracranial Meningioma’s Recurrences: Localized Versus Diffuse-Multicentric

Maiuri¹,

Corvino²,

Guadagno³

et al. 2021

Frontiers in Clinical Neurosurgery

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Meningiomas recur with a rate of 10–32% at ten years. Several features influence the risk of recurrence. Our aim is to define the pathological and surgical features at risk of diffuse-multicentric versus local-peripheral recurrence. Thirty-three cases of multicentric-diffuse recurrence of intracranial meningiomas were retrospectively analyzed and compared with 50 cases who experienced local-peripheral recurrence. The analyzed factors included age and sex, tumor location and shape, brain-tumor interface, entity of resection, WHO grade, Ki67 MIB1, progesterone receptor (PR) expression, number of reoperations, progression of WHO grade, and outcome. The multicentric-diffuse recurrences were mainly related to flat-shaped and Ki67 Li greater than 4% features at first surgery. Among patients with multicentric-diffuse recurrences, 25 underwent one to three reoperations; among them, 17 are alive with local tumor control or slow progression 2 to 25 years after the initial surgery versus only 2 out of 8 who did not undergo surgery. We conclude that flat-shaped meningiomas and those with Ki67 Li greater than 4% are at higher risk to recur in multicentric-diffuse pattern. Even multiple reoperations over a period of several years may obtain rather long survivals in selected patients with prevalent intradural not anaplastic tumors and not too extensive dural infiltration.

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Section: Data Of the Personal Seriesmentioning

confidence: 76%

Section: Data Of the Personal Seriesmentioning

confidence: 90%

“…According to their topography on the post-contrast magnetic resonance imaging (MRI) and surgical findings, the recurrences of meningiomas may be classified in 4 types [28]:…”

Section: Classification Of the Recurrencesmentioning

confidence: 99%

Section: Data Of the Personal Seriesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Topographic Distribution of Intracranial Meningioma’s Recurrences: Localized Versus Diffuse-Multicentric

Maiuri¹,

Corvino²,

Guadagno³

et al. 2021

Frontiers in Clinical Neurosurgery

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Mass spectrometry for neurosurgery: Intraoperative support in decision‐making

Pekov,

Bormotov,

Bocharova

et al. 2024

Mass Spectrometry Reviews

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Ambient ionization mass spectrometry was proved to be a powerful tool for oncological surgery. Still, it remains a translational technique on the way from laboratory to clinic. Brain surgery is the most sensitive to resection accuracy field since the balance between completeness of resection and minimization of nerve fiber damage determines patient outcome and quality of life. In this review, we summarize efforts made to develop various intraoperative support techniques for oncological neurosurgery and discuss difficulties arising on the way to clinical implementation of mass spectrometry‐guided brain surgery.

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Time to Recurrence of Meningiomas

Corvino

2024

Meningiomas

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Multicentric and diffuse recurrences of meningiomas

Cited by 19 publications

References 55 publications

Topographic Distribution of Intracranial Meningioma’s Recurrences: Localized Versus Diffuse-Multicentric

Topographic Distribution of Intracranial Meningioma’s Recurrences: Localized Versus Diffuse-Multicentric

Mass spectrometry for neurosurgery: Intraoperative support in decision‐making

Time to Recurrence of Meningiomas

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