Multicentric hemispheric ganglioglioma in a 20-year-old adult

Shirley, Peter; Tsui, Alpha; Kaye, Andrew H.

doi:10.1016/j.jocn.2014.08.003

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Gross total resection is the treatment of choice for WHO grade I and II gangliogliomas, and prognosis for patients with gross total resection is excellent. 3–5 To the best of our knowledge, only 5 cases with multifocal benign (WHO grade I or II) ganglioglioma exist in the literature, 6–10 all of which were located in the brain (one with extracranial in addition to intracranial presentation). Thus no guidelines currently exist regarding treatment of these multifocal lesions.…”

Section: Discussionmentioning

confidence: 99%

Genetic Characterization of a Multifocal Ganglioglioma Originating Within the Spinal Cord

et al. 2016

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BACKGROUND Gangliogliomas are rare, low-grade intra-axial tumors that exhibit both neuronal and glial components. Although the vast majority present as an intracranial lesion, a rare subset exist as isolated lesions of the spinal cord. Gangliogliomas have also been shown to harbor mutations in the p53 tumor suppressor gene and BRAF oncogene. Previous studies in ganglioglioma have correlated p53 mutations with histologic transformation and BRAF mutations with worse prognosis. CASE DESCRIPTION In this report, we describe a 35-year-old female who presented with multifocal ganglioglioma, involving both the conus medullaris and filum terminale. The dominant lesion in the filum terminale was resected, which revealed World Health Organization I grade, p53 mutant, and BRAF wildtype status. Our study documents the first report of a multifocal ganglioglioma, originating within the spinal cord. CONCLUSIONS Importantly, this case contradicts previous reports of p53 and BRAF mutations portending worsened tumor behavior and prognosis and demonstrates that further studies are needed to delineate the role of genetic characterization in the biologic understanding and management of gangliogliomas.

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Section: Discussionmentioning

confidence: 99%

Genetic Characterization of a Multifocal Ganglioglioma Originating Within the Spinal Cord

et al. 2016

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“…In these cases, the median progression-free survival (PFS) time is 9 months ( 36 ), which is similar to high-grade MCG. Special types include epithelioid GB ( 37 ), optic glioma ( 37 – 39 ), ganglion glioma ( 40 , 41 ), pilocytic astrocytoma ( 28 , 29 ), and oligodendroglioma ( 28 ) (clinical and pathological features are summarized in Table 1 ).…”

Section: Pathological Typesmentioning

confidence: 99%

Multicentric Glioma: An Ideal Model to Reveal the Mechanism of Glioma

Yan

Dai²,

Mei³

2022

Front. Oncol.

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As a special type of glioma, multicentric glioma provides an ideal pathological model for glioma research. According to the stem-cell-origin theory, multiple lesions of multicentric glioma share the same neuro-oncological origin, both in gene level and in cell level. Although the number of studies focusing on genetic evolution in gliomas with the model of multicentric gliomas were limited, some mutations, including IDH1 mutations, TERTp mutations and PTEN deletions, are found to be at an early stage in the process of genetic aberrance during glioma evolution based on the results of these studies. This article reviews the clinical reports and genetic studies of multicentric glioma, and intends to explain the various clinical phenomena of multicentric glioma from the perspective of genetic aberrance accumulation and tumor cell evolution. The malignant degree of a glioma is determined by both the tumorigenicity of early mutant genes, and the stemness of early suffered cells.

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An Integrative Survival Analysis for Multicentric Low-Grade Glioma

Wang

Yang

et al. 2020

World Neurosurgery

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Multicentric hemispheric ganglioglioma in a 20-year-old adult

Cited by 4 publications

References 20 publications

Genetic Characterization of a Multifocal Ganglioglioma Originating Within the Spinal Cord

Genetic Characterization of a Multifocal Ganglioglioma Originating Within the Spinal Cord

Multicentric Glioma: An Ideal Model to Reveal the Mechanism of Glioma

An Integrative Survival Analysis for Multicentric Low-Grade Glioma

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