Multicentric human papillomavirus–associated head and neck squamous cell carcinoma

Caley, A.; Evans, Mererid; Powell, Ned; Paleri, Vinidh; Tomkinson, Alun; Urbano, Teresa Guerrero; Jay, Amrita; Robinson, Max; Thavaraj, Selvam

doi:10.1002/hed.23584

Cited by 20 publications

(16 citation statements)

References 45 publications

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“…Synchronous tongue base carcinoma has been described in the literature, and bilateral tonsillectomy is insufficient to exclude additional malignancy at this site. 13 We found a high degree of similarity in the clinical characteristics…”

Section: Resultsmentioning

confidence: 65%

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Prevalence of synchronous bilateral tonsil squamous cell carcinoma: A retrospective study

Rokkjær

Klug

2017

Clinical Otolaryngology

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Objectives The prevalence of synchronous bilateral tonsil cancer remains unexplored. To date, only 38 cases have been described in the literature. With an aim to substantiate the Danish recommendation of performing bilateral tonsillectomy in patients with suspected or proven tonsil cancer and in patients with cervical carcinoma metastasis from an unknown primary tumour, this study was undertaken to determine the prevalence of synchronous bilateral tonsil cancer. Design A retrospective review of all patients diagnosed with tonsil cancer in the period 2000‐2015, Aarhus University Hospital, Denmark, was performed. Results Seven of 211 (3.3%) consecutive patients with tonsil cancer, who had undergone bilateral tonsillectomy (n = 180) or unilateral tonsillectomy (clinically normal side) combined with contralateral tonsil biopsy (side with suspected cancer) (n = 31), had synchronous bilateral tonsil cancer. Furthermore, dysplasia was found in the contralateral tonsil in two patients with unilateral tonsil cancer. Four of 171 (2.3%) patients with suspected unilateral tonsillar cancer had additional contralateral tonsil cancer. Three of 34 (8.8%) patients without clinical signs of tonsillar malignancy on any side (32 patients with carcinoma of unknown primary) had synchronous bilateral tonsil cancer. In none of the patients were bilateral tonsil cancer suspected. Patients with unilateral vs synchronous bilateral tonsil cancer had similar clinical and tumour characteristics. Conclusion Knowledge on additional contralateral synchronous tonsil cancer is crucial for avoidance of early recurrence of oropharyngeal cancer in patients with tonsil cancer. Based on our findings, we recommend bilateral tonsillectomy in all patients with suspected or proven tonsil cancer and carcinoma of unknown primary.

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Section: Resultsmentioning

confidence: 65%

“…Our data are limited to malignant findings in the tonsils and we did not evaluate synchronous tumours at any other anatomical site. Synchronous tongue base carcinoma has been described in the literature, and bilateral tonsillectomy is insufficient to exclude additional malignancy at this site …”

Section: Discussionmentioning

confidence: 99%

Prevalence of synchronous bilateral tonsil squamous cell carcinoma: A retrospective study

Rokkjær

Klug

2017

Clinical Otolaryngology

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“…The risk of another HPVpositive cancer occurring specifically in the head and neck is also low: approximately 4% in one small series. 41 Prophylactic vaccines can prevent oral human papillomavirus infection but will not help treat established cancers 41 Prophylactic vaccines can prevent oral human papillomavirus infection but will not help treat established cancers…”

Section: Human Papillomavirus May Persist After Treatmentmentioning

confidence: 99%

“…40 However, HPV-related cancers arising elsewhere in Waldeyer's ring (including the nasopharynx) have been reported occurring more than 5 years after the original diagnosis, and clinicians should be aware of this possibility during follow-up surveillance of patients. 41 Prophylactic vaccines can prevent oral human papillomavirus infection but will not help treat established cancers…”

Section: Risk Of Another Human Papillomavirus-related Cancer Is Lowmentioning

confidence: 99%

Sexual health in oral oncology: Breaking the news to patients with human papillomavirus–positive oropharyngeal cancer

Evans

Powell

2014

Head & Neck

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The incidence of oropharyngeal carcinoma is increasing in many countries of the developed world, largely because of cancers caused by infection with human papillomavirus (HPV). HPV-positive patients may ask questions that fall outside the remit of traditional consultations held in head and neck clinics. The purpose of this article is to highlight key messages about HPV and oropharyngeal cancer that are relevant to patients. Key messages include: HPV is a very common virus that transiently infects most people at some point in their lives; HPV infection is transmitted by normal sexual activity and is not a marker of promiscuity or abnormal sexual practices; HPV infections may be acquired many years before a cancer develops and infection does not imply recent infidelity; long-term partners of HPV-positive patients do not seem to be at increased risk of HPV infection.

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“…Devido às melhores respostas ao tratamento e prognóstico favorável dos pacientes afetados por tumores de cabeça e pescoço HPV positivos, tem-se estudado atualmente uma redução da intensidade do tratamento, a fim de não apenas avaliar a resposta diferencial à terapia, mas também minimizar a toxicidade do tratamento em longo prazo dos tratamentos. (Caley et al, 2013).…”

Section: Hpv E Tumores De Cabeça E Pescoçounclassified

Prevalência de HPV em tumores de cabeça e pescoço de São Paulo, Brasil

Betiol¹

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Multicentric human papillomavirus–associated head and neck squamous cell carcinoma

Cited by 20 publications

References 45 publications

Prevalence of synchronous bilateral tonsil squamous cell carcinoma: A retrospective study

Prevalence of synchronous bilateral tonsil squamous cell carcinoma: A retrospective study

Sexual health in oral oncology: Breaking the news to patients with human papillomavirus–positive oropharyngeal cancer

Prevalência de HPV em tumores de cabeça e pescoço de São Paulo, Brasil

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