Multicentric melano-ameloblastomata of the maxilla

Pontius, Edwin E.; Dziabis, Marvin D.; Foster, John A.

doi:10.1002/1097-0142(196503)18:3<381::aid-cncr2820180315>3.0.co;2-1

Cited by 28 publications

(1 citation statement)

References 15 publications

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“…However the occurrence of tumour in other anatomical locations such as skin, epididymis, uterus, ovary and mediastinum was independently described by Ashley et al 17 in 1964 and Dehner et al 18 in 1986. Pontius et al 19 in 1965 reported a case with occurrence of multiple lesions although MNTI generally occurs as solitary lesions. Pigmentation on the overlying soft tissue may be observed in only some cases.…”

Section: Discussionmentioning

confidence: 99%

Melanotic neuroectodermal tumour of infancy

Pattanayak

Ray²,

Richa³

et al. 2010

Case Reports

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Melanotic neuroectodermal tumour of infancy (MNTI) is a rare benign tumour of neural crest origin that was first described by Krompecher in 1918.1 It is predominantly found in infancy, with about 92% of cases below the age of 12 months and 82% below the age of 6 months. The predominant site of origin is in the premaxilla though it is reported at other sites also including the skull, the mandible, the epididymis and the brain.2 The lesions often have areas of bluish discolouration on the surface and are characterised by displacement of the involved tooth bud and local aggressiveness. The present report deals with two cases of MNTI, a 5-month-old baby girl and a 6-month-old baby boy who reported to the Department of Oral and Maxillofacial Pathology, Dr R Ahmed Dental College and Hospital, Kolkata, India. The clinical, radiological, histological and immunohistochemical findings, confirmed the diagnosis of MNTI. Flow cytometry was performed to analyse aneuploidy. The tumours were treated surgically with no history of recurrence to date.

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Section: Discussionmentioning

confidence: 99%

Melanotic neuroectodermal tumour of infancy

Pattanayak

Ray²,

Richa³

et al. 2010

Case Reports

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Melanotic neuroectodermal tumor of infancy

Koudstaal

Oldhoff

Panders

et al. 1968

Cancer

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Two cases of melanotic neuroectodermal tumor (melanotic progonoma) of in fancy are presented. In one, the tumor involved the temporal bone, which, to our knowledge, has not been previously reported. The histochemical enzyme pattern of these tumors is compared with that of certain other tumors thought to be derived from cells of the neural crest. The authors' findings offer further support for neural crest origin of these tumors.

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Melanotic neuroectodermal tumor of infancy: An ultrastructural study, literature review, and reevaluation

Cutler

Chaudhry

Topazian

1981

Cancer

171

105

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Two cases of melanotic neuroectodermal tumor of infancy were examined by electron microscopy and an extensive review of the literature was performed. Ultrastructural examination revealed several features not previously described for this lesion. Three different types of melanin granule formation were observed, many cells had a single cilium, and cell junctions of the "close" or "modified-tight" type were seen, but no desmosomes were found. The morphologic data were consistent with the concept that the tumor arises from neural crest cells. The review of the literature indicated that there have been 158 reported cases of this lesion, including the two reported here. There were five cases of malignant tumor reported for a rate of 3.2%. This rate of malignancy is very high in view of the fact that the tumor has been described as universally benign. The significance of this finding is discussed with regard to melanin-producing lesions of the oral cavity.

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Multicentric melano-ameloblastomata of the maxilla

Cited by 28 publications

References 15 publications

Melanotic neuroectodermal tumour of infancy

Melanotic neuroectodermal tumour of infancy

Melanotic neuroectodermal tumor of infancy

Melanotic neuroectodermal tumor of infancy: An ultrastructural study, literature review, and reevaluation

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