Multicentric osteolysis: report of the second successful renal transplant

Abstract

A patient with end stage renal disease due to sporadic idiopathic multicentric osteolysis (type 3 multicentric osteolysis) is described. His pre-transplant course was similar to those of previously described patients, while his post-transplant course has been uncomplicated. The pathology and pathogenesis of the nephropathy of sporadic idiopathic multicentric osteolysis is not well characterized. The short term outcome of renal transplantation is excellent in our patient and in the other similar case known to have been transplanted.

Inherited multicentric osteolysis with carpal-tarsal localisation mimicking juvenile idiopathic arthritis

“…No similar changes were found in heart, brain or systemic vessels [4,21]. Tyler and Rosenbaum [31] suggested the aetiology of the osteolysis and the severe nephropathy might be immune complex mediated: antibodies interacting with the basement membrane [12,30,31].…”

Carpal Osteolysis: An Unusual Entity Treated by Renal Transplantation

“…Only 13 cases of CTO associated with nephropathy have been reported [6,8,9, II], We have found only 2 other cases in the literature reporting successful renal trans plants in patients with CTO and ESRD [8,9], Although clinical improvement after transplantation has been de scribed [9], it is not known whether or not there is regres sion of bone lesions after the implantation of a renal graft. Interestingly, the X-ray findings of our patient clearly worsened, as is shown in figure 1.…”

“…The nephropathy appears more frequently in the sporadic form and it does not have specific features, appearing during childhood or adoles cence, with progression to end-stage renal disease (ESRD) in a variable period of time [4][5][6][7], We report here a case of a patient with sporadic CTO and renal failure that received a cadaveric renal transplant after treatment with continuous ambulatory peritoneal dialysis (CAPD). To our knowledge, there are only two previous cases successfully transplanted [8,9], Case Report A 14-year-old girl was admitted to the hospital to receive a renal transplant. Her previous medical history was unremarkable.…”

Osteolysis induced by AV-fistula in idiopathic carpotarsal osteolysis

“…The facial appearance is typical: exophtalmia, maxillar hypoplasia and micrognathia. Flexion contractures and Dupuytren-like contractures, thoracic scoliosis and corneal opacities were also described in other patients [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. An autosomal dominant (type I) and autosomal recessive (type II) inheritance, and a sporadic form (type III) have been described [15].…”

“…Nephropathy is seen more frequently in the sporadic form. It is characterized by fluctuating proteinuria, arterial hypertension and progressive renal functional impairment, with ESRD occurring from 1 to 17 years after the onset of proteinuria [1,3,4,[7][8][9][11][12][13][15][16][17]. The pathology and pathogenesis of the nephropathy is not well characterized.…”