Multicentric primary diffuse large B-cell lymphoma in genitourinary tract detected on 18F-fluorodeoxyglucose positron emission tomography with computed tomography: An uncommon presentation of a common malignancy

Abstract

Primary extranodal lymphomas (ENLs) are lymphomas with no or minor nodal involvement and a dominant extranodal component originating from any organ. Primary ENL originating in the genitourinary tract is extremely rare. Diffuse large B-cell lymphoma (DLBCL) is the most frequent histological subtype in primary genitourinary lymphoma. Lymphomatous involvement of genitourinary system organs is common in the setting of disseminated disease. Herein, we present a unique case of primary multicentric extranodal DLBCL of the urogenital system involving ureter, seminal vesicle, and penis detected on 18 fluro-deoxyglucose positron emission tomography with computed tomography, and to the best of our knowledge, it is the first case report with multiorgan involvement within a single (urogenital) organ system in a patient without disseminated disease, i.e., with no other nodal or extranodal organ system involvement.

Nasal-Type Extranodal Natural Killer/T-Cell Lymphoma Recurrence at Penile Glans Masquerading Urinary Contamination on 18F-FDG PET/CT

“…Distant metastasis of ENKTL commonly includes the skin, gastrointestinal tract, testis, eyes, lungs, breast, and central nervous system, 3,4 rarely reported in penis 5,6 . Penile involvement of lymphoma is mainly located in the penile shaft 7–9 and always accompanied by extrapenile lesions 9,10 . Unlike them, our case reported an isolated penile glans involvement of ENKTL-NT with intense FDG uptake.…”