Multicentric, randomized and positive-controlled study to assess the efficacy of an association of chondroitin sulphate, chitosan, l-selenomethionine and epigallocatechin-3-gallate in the control of osteoarthritis and functional postoperative recovery

Pucheu, Bertrand; Duhautois, Bruno

doi:10.1016/j.anicom.2009.03.001

Cited by 1 publication

(1 citation statement)

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“…It is believed that some nutraceuticals provide the body with several nutrients, essential for cartilage repair and reduction of inflammation (BIERER and BUI, 2002). So far there has been no evidence to suggest that nutraceuticals are associated with adverse effects (PUCHEU and DUHAUTOIS, 2009). However, there is conflicting evidence regarding the efficacy of these products.…”

Section: Introductionmentioning

confidence: 99%

The efficacy of neutraceuticals to alleviate dog osteoarthritis symptoms, a meta-analysis of case-control trials

Mata,

Dormer

2023

Vet. Arh

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Osteoarthritis is a common condition in dogs. Non-steroidal anti-inflammatory drugs are currently the most widely used treatment option; however, their chronic use is associated with numerous malefic side effects, including death. There has been increased interest in alternative treatments and nutraceuticals have assumed fundamental importance. A number of individual studies and systematic reviews have been done, but no meta-analysis has been produced to date. By conducting a meta-analysis, we aimed to fill this research gap. We combined the results of 13 case placebo controlled trials in a single major study, to determine the efficacy of nutraceuticals in alleviating symptoms of osteoarthritis. A population of 638 dogs was used, from which 327 were treated with nutraceuticals and 321 were used as controls. A successful random effects model was adjusted (P<0.001), with a risk ratio of 0.62 within a 95% CI of [0.47; 0.81], favouring the use of nutraceuticals. The nutraceuticals used in the trials were green-lipped mussel, chondroitin sulphate, an extract of India and Java turmeric (P54FP), a homeopathic combination preparation known as Zeel®, Ω-3 fatty acids, deep sea fish oil, a mix of glucosamine with chondroitin sulphate and hyaluronic acid, and cannabidiol.

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Section: Introductionmentioning

confidence: 99%