Multicentric Reticulohistiocytosis

Guillén, C.; Fortea, José M.; Serrano, Gabriel; Martorell, Miguel; Cogollos, Emilio; Alegre, V.; Aliaga, Adolfo

doi:10.1159/000249618

Cited by 17 publications

(10 citation statements)

References 6 publications

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“…Therapies with corticosteroids, hydroxychloroquine, methotrexate, alkylating agents such as chlorambucil and cyclophosphamide, and azathioprine have been used with mixed success. [1][2][3][4] The challenge in this case was to determine a safe and effective treatment for both the skin and joint manifestations of the disease.…”

Section: Therapeutic Challengementioning

confidence: 99%

Treatment of Multicentric Reticulohistiocytosis With Etanercept

Kovach¹

2004

Arch Dermatol

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Section: Therapeutic Challengementioning

confidence: 99%

Treatment of Multicentric Reticulohistiocytosis With Etanercept

Kovach¹

2004

Arch Dermatol

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“…These findings strongly suggest that the improvement of multicentric reticulohistiocytosis could be accounted for by the alendronate treatment. In the case reports of multicentric reticulohistiocytosis described thus far, more aggressive therapy, such as a combination of corticosteroids with immunosuppressive agents (3, 13–15), has met with some success, although a satisfactory result was not obtained, and sometimes there were severe adverse effects, such as nephrotoxicity, myelosuppression, and lymphocytopenia (3, 4).…”

Section: Discussionmentioning

confidence: 99%

Synthesis of water‐soluble thermosensitive polymers having phosphonium groups from methacryloyloxyethyl trialkyl phosphonium chlorides–N‐isopropylacrylamide copolymers and their functions

Nonaka

Ogata

et al. 2002

J of Applied Polymer Sci

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Water-soluble thermosensitive polymers having phosphonium groups were synthesized by the copolymerization of N-isopropylacrylamide (NIPAAm) with methacryloyloxyethyl trialkyl phosphonium chlorides (METRs) having varying alkyl lengths. The relative viscosities of the copolymer solutions increased with increasing content of phosphonium groups in the copolymers and decreased with increasing chain length of alkyl chains in the phosphonium groups. However, the copolymers of METR with octyl groups in phosphonium groups (METO) and NIPAAm became water insoluble with increasing contents of METO moieties in the copolymers. The transmittance at 660 nm of the copolymer solutions above the lower critical solution temperature (LCST) decreased gradually with increasing temperature and decreased with increasing chain length of alkyl chains in the phosphonium groups. The transmittance at 660 nm of the copolymer solutions above the LCST was greatly affected by the addition of neutral salts such as KCl. The copolymers of METR with ethyl groups in phosphonium groups and NIPAAm and those of METR with butyl groups in phosphonium groups and NIPAAm had high flocculating abilities against bacterial suspensions. The METO-NIPAAm copolymer was found to have a high antibacterial activity. The flocculating ability and the antibacterial activity of the copolymers were affected by not only the content of phosphonium groups but also the alkyl chain length in the phosphonium groups in the copolymers.

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“…[10][11][12][13] Our case suggests a role for azathioprine in the treatment of the cutaneous and arthritic manifestations of MRH. Further support for this is provided by the disease recurring upon cessation of azathioprine and resolution with its re-introduction.…”

Section: Case Reportmentioning

confidence: 99%

A case of multicentric reticulohistiocytosis responsive to azathioprine in a patient with no underlying malignancy

Rudd¹,

Dolianitis²,

Varigos³

et al. 2011

Australasian Journal of Dermatology

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Multicentric reticulohistiocytosis (MRH), a rare histiocytic systemic condition characterized by mutilating arthritis and multiple cutaneous nodules, has been associated with malignancy including that of the breast, thyroid and colon. An unsubstantiated link with infectious agents such as mycobacterium tuberculosis has been described. Many treatments have been used with varying success. We describe the case of a 60-year-old man with MRH and no underlying malignancy who initially responded well to azathioprine and whose disease recurred upon cessation. A second course of azathioprine administered in conjunction with antituberculous treatment resulted in disease control. Broader associations and features of this rare disease are discussed.

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Multicentric Reticulohistiocytosis

Cited by 17 publications

References 6 publications

Treatment of Multicentric Reticulohistiocytosis With Etanercept

Treatment of Multicentric Reticulohistiocytosis With Etanercept

Synthesis of water‐soluble thermosensitive polymers having phosphonium groups from methacryloyloxyethyl trialkyl phosphonium chlorides–N‐isopropylacrylamide copolymers and their functions

A case of multicentric reticulohistiocytosis responsive to azathioprine in a patient with no underlying malignancy

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