Multicentric reticulohistiocytosis

Luz, FB; Gaspar, AP; Kalil-Gaspar, Neide; Ramos‐e‐Silva, Márcia

doi:10.1046/j.1468-3083.2001.00362.x

Cited by 124 publications

(157 citation statements)

References 71 publications

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“…CD68 is also a member of the scavenger receptor family and typically functions to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Based on immunohistochemistry, CD68 is histiocytic (similar to the T-lymphocytic marker CD3) and is associated with multicentric reticulohistiocytosis [41] , rheumatoid arthritis [42] , Crohn's disease [43] , and vasculitic neuropathies [44] . Besides the genes mentioned above, the gene expression of other NF-κB downregulated genes, including SAA2, LTB, TNFRSF9, was confirmed by real-time qRT-PCR.…”

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Microarray analysis reveals the inhibition of nuclear factor-kappa B signaling by aristolochic acid in normal human kidney (HK-2) cells

Chen

Chiang

et al. 2010

Acta Pharmacol Sin

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Aim: To study the molecular mechanism underlying the effect of aristolochic acid (AA), a major active component of plants from the Aristolochiaceae family using microarray analysis. Methods: Human kidney (HK-2) cells were treated with AA (0, 10, 30, and 90 μmol/L) for 24 h, and the cell viability was measured by a 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide assay. Complementary DNA microarrays were used to investigate the gene expression pattern of HK-2 cells exposed to AA in triplicate. A quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) assay was used to verify the microarray data for selected nuclear factor kappa B (NF-κB)-regulated genes. Furthermore, the subcellular localization of NF-κB p65 was visualized by immunofluorescence confocal microscopy in HK-2 cells. The NF-κB activity was examined by a luciferase reporter assay in HK-2/NF-κB transgenic cells. Results: AA exhibited a dose-dependent cytotoxic effect in HK-2 cells and induced alterations in the gene expression profiles related to the DNA damage response, DNA repair, macromolecule metabolic process, carbohydrate metabolic process, DNA metabolic process, apoptosis, cell cycle, and transcription. In addition, 9 biological pathways associated with immunomodulatory functions were downregulated in AA-treated HK-2 cells. A network analysis revealed that NF-κB played a central role in the network topology. Among NF-κB-regulated genes, 8 differentially expressed genes were verified by qRT-PCR. The inhibition of NF-κB activity by AA was further confirmed by immunofluorescence confocal microscopy and by NF-κB luciferase reporter assay. Conclusion: Our data revealed that AA could suppress NF-κB activity in normal human cells, perhaps partially accounting for the reported anti-inflammatory effects of some plants from the genus Aristolochia.Keywords: aristolochic acid; microarray analysis; nuclear factor-kappa B; human kidney HK-2 cells; confocal microscopy; luciferase reporter assay Acta Pharmacologica Sinica (2010) 31: 227-236; doi: 10.1038/aps.2009 Original Article # These authors contributed equally to this work. * To whom correspondence should be addressed. [7,8] . AA was found to possess anti-inflammation effects as demonstrated by its ability to inhibit phospholipase A 2 (PLA 2 ) when administered by intramuscular or intraperitoneal injection [9,10] . Furthermore, AA was also reported to inhibit Group I PLA 2 in humans with sepsis [11] . From in vitro studies, AA has been shown to suppress phospholipohydration of PLA 2 derived from human synovial fluid, cobra venom, porcine pancreas, and human platelets [12] . The anti-inflammatory activities of AA in different models of inflammation have promoted its use in many countries in herbal formulations for arthritis, rheumatism, gout and chronic inflammatory skin diseases [13,14] . Moreover, double-blind studies in healthy volunteers show that AA increased the phagocytic activity of peripheral granulocytes after treatment with AA 0.9 mg/d for three to ten consecutive days [...

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confidence: 99%

Microarray analysis reveals the inhibition of nuclear factor-kappa B signaling by aristolochic acid in normal human kidney (HK-2) cells

Chen

Chiang

et al. 2010

Acta Pharmacol Sin

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“…3 Como em todas as histiocitoses, há ativação descontrolada de macrófagos e liberação de citocinas e outros produtos que promovem proliferação macrofágica e fagocitose. Também verifica-se aumento de IL-12, IL-1b, IL-6 e TNF alfa.…”

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“…Pequenas tumefações ao redor das unhas são achados clínicos típicos (27% dos pacientes) chamadas de coral de contas (coral beads). 3 Além do coral de contas há outros dois sinais patognomônicos: xantelasma palpebral (17%) e lesões vermiculares ao redor das narinas (15%). 3 As lesões cutâneas freqüentemente se resolvem antes do quadro articular e podem deixar seqüe-las permanentes.…”

Section: Discussionunclassified

“…3 Além do coral de contas há outros dois sinais patognomônicos: xantelasma palpebral (17%) e lesões vermiculares ao redor das narinas (15%). 3 As lesões cutâneas freqüentemente se resolvem antes do quadro articular e podem deixar seqüe-las permanentes. 8 Nos casos mais graves, a desfiguração da face é conhecida como "face leonina".…”

Section: Discussionunclassified

“…9 Constituem diagnósticos diferenciais: sarcoidose, hanseníase virchowiana, granuloma anular, xantoma, xantogranuloma, fibroxantoma, linfoma, lipoidoproteinose e doença de Faber. 3 As manifestações articulares caracterizam-se por poliartrite progressiva, difusa e simétrica. Os locais mais afetados são: mãos, joelhos, punhos, ombros, cotovelos, tornozelos, quadril, pés, pescoço e coluna.…”

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Remissão de retículo-histiocitose multicêntrica com terapia combinada com infliximabe

Rstom

Menezes

Maitto

et al. 2008

An. Bras. Dermatol.

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A retículo-histiocitose multicêntrica é doença sistêmica rara e de etiologia desconhecida. Caracterizase por poliartrite simétrica, que pode evoluir para artrite mutilante, e por lesões papulonodulares na pele e nas mucosas. O diagnóstico definitivo é histopatológico. Em aproximadamente um terço dos casos de retículo-histiocitose multicêntrica em adultos, observa-se associação com malignidade. Ainda não foi estabelecida uma terapia-padrão. Descreve-se o caso de mulher de 46 anos com quadro clínico característico de retículo-histiocitose multicêntrica. Realizou-se tratamento inovador à base de infliximabe, obtendo-se ótimos resultados.

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Treatment of Multicentric Reticulohistiocytosis With Etanercept

Kovach¹

2004

Arch Dermatol

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Multicentric reticulohistiocytosis

Abstract: MR is a unique histiocytic proliferative disease with a peculiar immunophenotypic pattern and distinctive clinical and histopathological aspects.

Cited by 124 publications

References 71 publications

Microarray analysis reveals the inhibition of nuclear factor-kappa B signaling by aristolochic acid in normal human kidney (HK-2) cells

Microarray analysis reveals the inhibition of nuclear factor-kappa B signaling by aristolochic acid in normal human kidney (HK-2) cells

Remissão de retículo-histiocitose multicêntrica com terapia combinada com infliximabe

Treatment of Multicentric Reticulohistiocytosis With Etanercept

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