Multicentric reticulohistiocytosis misdiagnosed as rheumatoid arthritis

Keum, Dong In; Yoon, Na-Young; Lee, Won‐Soo

doi:10.1111/ijd.12333

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…Periodic acid Schiff staining is positive, and immunohistochemistry reveals CD68 positivity (+), although T and B lymphocytes and Langerhans cell markers are primarily negative. Although MRH can mimic RA, [ 3 ] it also has different characteristics. Multiple articular bone destruction can occur in the early stage of MRH, mostly involving the distal interphalangeal joints.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of a patient with rheumatoid arthritis and comorbid multicentric reticulohistiocytosis

Chang

Wang

et al. 2022

Rheumatology and Immunology Research

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Multicentric reticulohistiocytosis (MRH) is a rare disease of unknown pathogenesis, characterized by skin histiocytosis and destructive arthritis. The present study describes a 53-year-old woman who presented with rheumatoid arthritis (RA) and MRH, which is a clinically rare entity. Diagnosis of MRH was based on nodule pathology. Meanwhile, the patient had typical arthritis, was positive for serum anti-cyclic citrullinated peptide (anti-CCP) antibodies and synovitis confirmed by joint ultrasound, and was diagnosed with RA. Her symptoms resolved with glucocorticoids and methotrexate.

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Section: Discussionmentioning

confidence: 99%

Successful treatment of a patient with rheumatoid arthritis and comorbid multicentric reticulohistiocytosis

Chang

Wang

et al. 2022

Rheumatology and Immunology Research

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Multicentric Reticulohistiocytosis: a Critical Review

et al. 2015

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The literature reports approximately 300 cases of multicentric reticulohistiocytosis (MRH) worldwide, mostly women of Caucasian origin. MRH manifests as a symmetric erosive polyarthritis mimicking rheumatoid arthritis with the subsequent appearance of typical papulonodular skin lesions. The disease may rapidly progress towards mutilans arthritis in the majority of cases, but it generally remits spontaneously in 10 years. The only diagnostic hallmark for MRH is the observation at histology of numerous histiocytes and multinucleated giant cells and ground glass eosinophilic cytoplasm. Despite its rarity, clinical and pathogenetic challenging features characterize the condition. First, the differential diagnosis with other forms of arthritis and the frequent coexistence of neoplasms or autoimmune diseases warrant a careful evaluation of suspected cases. Second, data from isolated MRH cases are consistent in supporting a role for monocyte/macrophage cells and for an enhanced osteoclastic activity in the affected tissues. Third, beside anti-inflammatory treatments, promising reports suggest that biologics targeting TNF-alpha and bisphosphonates may prove beneficial in MRH. Based on these observations, we are convinced that our understanding of this rare condition may prove beneficial in mechanistic advancement for other more prevalent inflammatory conditions such as arthritidies and other bone diseases.

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Causes de polyarthrite - polyarthralgies pouvant simuler une polyarthrite rhumatoïde

Lucas

Perdriger

2018

Revue du Rhumatisme Monographies

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Multicentric reticulohistiocytosis misdiagnosed as rheumatoid arthritis

Cited by 5 publications

References 10 publications

Successful treatment of a patient with rheumatoid arthritis and comorbid multicentric reticulohistiocytosis

Successful treatment of a patient with rheumatoid arthritis and comorbid multicentric reticulohistiocytosis

Multicentric Reticulohistiocytosis: a Critical Review

Causes de polyarthrite - polyarthralgies pouvant simuler une polyarthrite rhumatoïde

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