Multicentric Study Comparing Intravesical Chemotherapy Alone and With Local Microwave Hyperthermia for Prophylaxis of Recurrence of Superficial Transitional Cell Carcinoma

Abstract

In our series, endovesical thermochemotherapy appears to be more effective than standard endovesical chemotherapy as an adjuvant treatment for superficial bladder tumors at 24-month follow-up, despite an increased but acceptable local toxicity.

Hyperthermia, Radiation and Chemotherapy: The Role of Heat in Multidisciplinary Cancer Care

“…Freedom from tumor recurrence, the primary endpoint was significantly improved with addition of hyperthermia to 83% as compared to 42% with mitomycin C alone. (93) In a subsequent report of long-term results, this benefit was maintained with median follow-up for tumor free patients of 91 months. 10 disease-free survival was 53% vs. 15%…”

Impact of silicone and metal port-a-cath implants on superficial hyperthermia treatment quality

“…Although only a small number of these patient have a port-a-cath in the re-irradiation field, a good knowledge on how and to what extent a metal or silicone port-a-cath disturbs the SAR distribution of an applicator is important for a safe and effective superficial hyperthermia treatment. Further, we notice there is a growing discussion [18] towards the combination of hyperthermia with chemotherapy [19][20][21][22][23]. In that patient group, inclusion of a porta-cath in the hyperthermia treatment field might be a more regular occurrence, and hence stresses the need to know how close to the port-a-cath we can heat.…”

Chemohyperthermia in non-muscle-invasive bladder cancer: An overview of the literature and recommendations

“…In a multicentre, prospective, randomised trial, Colombo et al evaluated the efficacy of adjuvant CHT in 83 patients with primary or recurrent NMIBC [21]. Patients were randomised following TURB complete transurethral resection of bladder tumour to chemotherapy alone (MMC, 41 patients) or chemotherapy combined with hyperthermia (MMC þ HT, 42 patients).…”

“…Posterior wall thermal reaction, a phenomenon typically seen on cystoscopy after microwave-induced CHT, is caused by the location of the RF antenna. It appears as a medallion-shaped discoloured scar-like patch, which in general resolves spontaneously and is not associated with symptoms [9][10][11]21,[23][24][25][26][27][28][29][30].…”