Multicentric variant of peripheral ossifying fibroma

Abstract

Peripheral ossifying fibroma (POF) is a solitary over growth of the gingiva known to arise from the cells of the periodontal ligament. The lesions usually start as a painless overgrowth of the interdental papilla unless associated with trauma and gradually involve the other counter parts of the gingiva. The lesion is more considered to be an inflammatory or reactive process rather than to be neoplastic. Here, the authors present a unique case of multiple POF in a young male adult aged 24 years where surgical excision was carried out quadrant wise. The biopsy specimen from multiple sites revealed similar histopathologic features consistent with POF, but also with the multicentric presentation of POF, which is a unique phenomenon. Multicentric variant of POF is indeed a rare case being only the second case so far which has been documented. Management of such case needs a multidisciplinary approach to prevent the recurrence along with regular long time follow-up.

Large peripheral ossifying fibroma interfering with the normal functions of the oral cavity: A rare case report presentation and discussion

“…Only few cases have been reported in the literature with multicentric variants of POF. For instance, multicentric lesions have been reported in conditions associated with rare genetic alteration such as multiple neuromas, Gardener's syndrome, multiple neuromas, nevoid basal cell carcinoma syndrome [ 7 ].…”

Coverage Root after Removing Peripheral Ossifying Fibroma: 5-Year Follow-Up Case Report

“…There is a mesenchymal cell of the periodontal ligament and/or cementum proliferation that are induced by such local irritants. The displacement and mobility of the teeth are uncommon, unless preexisting periodontal disease is found or in cases where the teeth are erupting [4]. …”

“…There is a predilection for the anterior portion of the jaws [4, 5]. Sometimes it extends throughout the teeth, involving both the facial and the lingual gum [4]. There may be bleeding when the lesion is touched or even spontaneously, but mainly when it is constantly traumatized.…”

“…Women are affected more often than men by this injury, which occurs predominantly in the second decade of life [4, 5] and in Caucasians [3, 5], accounting for 9.6% of gingival lesions [6]. …”

“…Furthermore, one should remove any identifiable causative agent [1, 4, 6]. There may be recurrence [4, 6], but its risk is diminished if the excision is performed under the periosteum [2, 6]. …”