Multichannel Wireless-Electrodeless Quartz-Crystal Microbalance Immunosensor

Ogi, Hirotsugu; Nagai, Hidetaka; Fukunishi, Yuji; Yanagida, Takeshi; Hirao, Masahiko; Nishiyama, Masayoshi

doi:10.1021/ac100527r

Cited by 34 publications

(26 citation statements)

References 32 publications

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“…The formation of phospholipid bilayers was used as a test case and total sample volumes were twenty fold lower than commercial QCM equipment (Ohlsson et al ., ). Furthermore, a wireless QCM system was developed where the shear vibration excitation and detection was achieved using antennas and the system was demonstrated using antigen‐antibody interactions (Ogi et al ., ).…”

Section: Technical Developments and Novel Applicationsmentioning

confidence: 97%

A Survey of the 2010 Quartz Crystal Microbalance Literature

Speight

Cooper

2012

J of Molecular Recognition

135

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In 2010 there has again been an increase in the number of papers published involving piezoelectric acoustic sensors, or quartz crystal microbalances (QCM), when compared to the last period reviewed 2006-2009. The average number of QCM publications per annum was 124 in the period 2001-2005, 223 in the period 2006-9, and 273 in 2010. There are trends towards increasing use of QCM in the study of protein adsorption to surfaces (93% increase), homeostasis (67% increase), protein-protein interactions (40% increase), and carbohydrates (43% increase). New commercial systems have been released that are driving the uptake of the technology for characterisation of binding specificities, affinities, kinetics and conformational changes associated with a molecular recognition event. This article highlights theoretical and practical aspects of the principals that underpin acoustic analysis, then reviews exemplary papers in key application areas involving small molecular weight ligands, carbohydrates, proteins, nucleic acids, viruses, bacteria, cells, and membrane interfaces.

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Section: Technical Developments and Novel Applicationsmentioning

confidence: 97%

A Survey of the 2010 Quartz Crystal Microbalance Literature

Speight

Cooper

2012

J of Molecular Recognition

135

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“…A recent extension of the technique allows the simultaneous measurement of energy dissipation and provides new insight into the protein adsorption process. Using QCM, multichannel detection is possible on a one-chip system [86]. …”

Section: Label-free Detectionmentioning

confidence: 99%

Label and Label-Free Detection Techniques for Protein Microarrays

et al. 2015

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Protein microarray technology has gone through numerous innovative developments in recent decades. In this review, we focus on the development of protein detection methods embedded in the technology. Early microarrays utilized useful chromophores and versatile biochemical techniques dominated by high-throughput illumination. Recently, the realization of label-free techniques has been greatly advanced by the combination of knowledge in material sciences, computational design and nanofabrication. These rapidly advancing techniques aim to provide data without the intervention of label molecules. Here, we present a brief overview of this remarkable innovation from the perspectives of label and label-free techniques in transducing nano-biological events.

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“…For example, a much used biosensor is based on the quartz crystal microbalance which can convert specific receptor/ligand interactions into a change in resonant frequency of a quartz crystal (Ogi et al, 2010;Saitakis et al, 2010). In the case that no dynamic mechanical or electronic function is to be performed by the device, the interface can be considered as biomaterial.…”

Section: Definition Of the Bio-machine Interfacementioning

confidence: 99%