Sports performance prediction has gradually become a research hotspot in various colleges and universities, and colleges and universities pay more and more attention to the development of college students’ comprehensive quality. Aiming at the problems of low accuracy and slow convergence of the existing college students’ sports performance prediction models, a method of college students’ sports performance prediction based on improved BP neural network is proposed. First, preprocess the student’s sports performance data, then use the BP neural network to train the data samples, optimize the selection of weights and thresholds in the neural network through the DE algorithm, and establish an optimal college student’s sports performance prediction model, and then based on cloud computing, the platform implements and runs the sports performance prediction model, which speeds up the prediction of sports performance. The results show that the model can improve the accuracy of college students’ sports performance prediction, provide more reliable prediction results, and provide valuable information for sports training.