Multicompartment colloid systems with lipid and polymer membranes for biomedical applications

Koroleva, M. Yu.

doi:10.1039/d3cp01984e

Phys. Chem. Chem. Phys.

2023

DOI: 10.1039/d3cp01984e

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Multicompartment colloid systems with lipid and polymer membranes for biomedical applications

M. Yu. Koroleva

Abstract: Multicompartment structures have the potential for biomedical applications because they can act as multifunctional systems and provide simultaneous delivery of drugs and diagnostic agents of different natures. Moreover, some of...

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2024

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Cited by 7 publications

References 240 publications

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Unveiling Hierarchical Self‐Assembly of Triazolylferrocenyl Dendrimers: Producing Non‐Traditional Intrinsically Green Fluorescent Vesosomes for Nanotheranostics

Braga,

Perli,

Wang

et al. 2024

Adv Healthcare Materials

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Dendrimers and supramolecular chemistry continue to fascinate researchers due to the endless unrevealed potential of their combination. This study investigates the self‐assembly process of a series of hydrophobic triazolylferrocenyl dendrimers in aqueous medium. Deep investigation through NMR spectroscopy, absorption UV–vis spectroscopy along with theoretical simulations demonstrates that the ferrocenyl moieties interact intramolecularly and intermolecularly driving the self‐assembly process. Data obtained by DLS, NTA, SEM, TEM, and EF‐TEM demonstrate that these dendrimers, in water, spontaneously self‐assemble through a hierarchical process. The dendrimers first self‐assemble into uniform nanovesicles, which in turn self‐assemble into larger vesosomes. The resulting vesosomes emit green non‐traditional intrinsic fluorescence, which is a property that emerged from the self‐assembled architectures. The vesosomes are efficiently uptaken by cancer cells and induce significant cytotoxic activity against the cancer cell line MCF‐7, up to the submicromolar concentration. Positive dendritic effects are identified in the fluorescence intensity and in the cytotoxic activity of the vesosomes, which follow the trend G0‐9Fc < G1‐27Fc < G2‐81Fc. This work showcases the remarkable potential of combining the two dynamic fields of dendrimers and supramolecular chemistry, which resulted in green fluorescent vesosomes capable of performing the dual role of cell imaging and killing, with potential applications in nanotheranostics.

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Unveiling Hierarchical Self‐Assembly of Triazolylferrocenyl Dendrimers: Producing Non‐Traditional Intrinsically Green Fluorescent Vesosomes for Nanotheranostics

Braga,

Perli,

Wang

et al. 2024

Adv Healthcare Materials

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Complex Droplet Microreactor for Highly Efficient and Controllable Esterification and Cascade Reactions

Wei,

Yin,

et al. 2024

ChemSusChem

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A highly efficient complex emulsion microreactor has been successfully developed for multiphasic water‐labile reactions, providing a powerful platform for atom economy and spatiotemporal control of reaction kinetics. Complex emulsions, composing a hydrocarbon phase (H) and a fluorocarbon phase (F) dispersed in an aqueous phase (W), are fabricated in batch scale with precisely controlled droplet morphologies. A biphasic esterification reaction between 2‐bromo‐1,2‐diphenylethane‐1‐ol (BPO) and perfluoro‐heptanoic acid (PFHA) is chosen as a reversible and water‐labile reaction model. The conversion reaches up to 100% under mild temperature without agitation, even with nearly equivalent amounts of reactants. This efficiency surpasses all reported single emulsion microreactors, i.e., 84~95%, stabilized by various emulsifiers with different catalysts, which typically necessitate continuous stirring, a high excess of one reactant, and/or extended reaction time. Furthermore, over 3 times regulation threshold in conversion rate is attained by manipulating the droplet morphologies, including size and topology, e.g., transition from completely engulfed F/H/W double to partially engulfed (F+H)/W Janus. Addition‐esterification, serving as a model for triple phasic cascade reaction, is also successfully implemented under agitating‐free and mild temperature with controlled reaction kinetics, demonstrating the versatility and effectiveness of the complex emulsion microreactor.

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Easy, Rapid and High‐Throughput Production of Single and Multicompartment Liposomes by Vortex Emulsification

Luo,

Shi,

Deng

2024

ChemSystemsChem

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Cell‐sized liposomes, the self‐assembled phospholipid vesicles with bilayer membranes, have garnered substantial attention across various fields, particularly as cell mimics. In this study, we introduce a simplified method for rapidly producing single‐ and multicompartment liposomes using a common laboratory vortex mixer. The simplicity of our method has the potential to greatly facilitate artificial cell and tissue‐related research, potentially leading to broader applications of liposomes.

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Multicompartment colloid systems with lipid and polymer membranes for biomedical applications

Abstract: Multicompartment structures have the potential for biomedical applications because they can act as multifunctional systems and provide simultaneous delivery of drugs and diagnostic agents of different natures. Moreover, some of...

Cited by 7 publications

References 240 publications

Unveiling Hierarchical Self‐Assembly of Triazolylferrocenyl Dendrimers: Producing Non‐Traditional Intrinsically Green Fluorescent Vesosomes for Nanotheranostics

Unveiling Hierarchical Self‐Assembly of Triazolylferrocenyl Dendrimers: Producing Non‐Traditional Intrinsically Green Fluorescent Vesosomes for Nanotheranostics

Complex Droplet Microreactor for Highly Efficient and Controllable Esterification and Cascade Reactions

Easy, Rapid and High‐Throughput Production of Single and Multicompartment Liposomes by Vortex Emulsification

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