Multicompartment systems: A putative carrier for combined drug delivery and targeting

Gautam, Laxmikant; Shrivastava, Priya; Yadav, Bhavana; Jain, Anamika; Sharma, Rajeev; Vyas, Sonal

doi:10.1016/j.drudis.2021.12.007

Cited by 15 publications

(7 citation statements)

References 103 publications

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“…We chose PEG-DSPE, polyethyleneglycol-(1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)]), as a POI binding linker since PEG-DSPE is highly biocompatible and has been approved by the U.S. Food and Drug Administration (FDA) for drug delivery 16 . Antibodies are chosen as the POI binder, considering their high affinity to POIs and the fact that antibody‒drug constructs are well accepted clinically 17 .…”

Section: Resultsmentioning

confidence: 99%

Targeted Protein Degradation via Nanoparticles

Liu

Dong

et al. 2022

Preprint

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Strategies that hijack selective proteins of interest (POIs) to the intracellular protein recycling machinery for targeted protein degradation (TPD) have recently emerged as powerful tools for undruggable targets in biomedical research and the pharmaceutical industry. However, targeting any new POI with current TPD tools requires laborious case-by-case design for different diseases and cell types, especially for those extracellular targets. Here, we observed that nanoparticles (NPs) can mediate the receptor-free internalization of hijacked protein and further developed a generic paradigm for both intra- and extracellular POI degradation, by making full use of clinically approved components. The phenomenon is general, as we found nanostructures such as lipid nanoparticle (LNP), liposomes, exosomes, polymeric nanoparticles, inorganic nanoparticles and their hybrid nanoparticles modified with POI-recognizing moiety (antibody, peptides, small molecule drugs) can mediate TPD for a wide range of extracellular/membrane and intracellular targets. The super flexible and feasible-to-synthesize TPD-NPs paradigm may revolutionize the current TPD tools development landscape and it provides fundamental knowledge to receptor mediated drug therapies.

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Section: Resultsmentioning

confidence: 99%

Targeted Protein Degradation via Nanoparticles

Liu

Dong

et al. 2022

Preprint

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“…The size of the larger liposome typically ranges from a few hundred nanometers to tens of micrometers, and they are often named large unilamellar vesicles (LUVs, <1 μm) or giant unilamellar vesicles (GUVs, >1 μm). Vesosomes are superior to liposomes due to a few unique aspects: (i) multiple compartments can be loaded in separate liposomes, (ii) drug retention time can be increased, and (iii) the delivery system can be more delicately controlled and targeted to allow payloads to be held in space independently. − In addition, the major drawback of liposomes is the undesirable release of drug contents at nontarget sites in physiological environments, but this effect can be minimized with vesosomes by providing an additional outermost layer to envelop the inner liposomes . Due to the double barrier that allows sustained drug release, the amount of drug released can be precisely controlled to give the same therapeutic effect, minimizing possible side effects associated with overdose. , …”

Section: Introductionmentioning

confidence: 99%

Multicomponent-Loaded Vesosomal Drug Carrier for Controlled and Sustained Compound Release

Lee,

Song,

Kim

et al. 2023

Biomacromolecules

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Liposomes have been extensively adopted in drug delivery systems with clinically approved formulations. However, hurdles remain in terms of loading multiple components and precisely controlling their release. Herein, we report a vesosomal carrier composed of liposomes encapsulated inside the core of another liposome for the controlled and sustained release of multiple contents. The inner liposomes are made of lipids with different compositions and are co-encapsulated with a photosensitizer. Upon induction of reactive oxygen species (ROS), the contents of the liposomes are released, with each type of liposome displaying distinct kinetics due to the variance in lipid peroxidation for differential structural deformation. In vitro experiments demonstrated immediate content release from ROS-vulnerable liposomes, followed by sustained release from ROS-nonvulnerable liposomes. Moreover, the release trigger was validated at the organismal level using Caenorhabditis elegans. This study demonstrates a promising platform for more precisely controlling the release of multiple components.

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“…Multi-compartmentalized materials have a structure that confines two or more distinct domains loaded with different cargoes, which are simultaneously transported and are spatially separated. 26,27 Recently, examples of multi-compartment liposomes, [28][29][30] polymersomes, [31][32][33] microgels, 34,35 and capsosomes, [36][37][38] have emerged as vehicles for multi-drug delivery, 35,39 as hierarchical microreactors, 40 and as cell mimics. 41,42 However, their realization requires either multiple emulsification steps to produce double emulsion droplets or additional post-chemical reactions to form the compartments.…”

Section: Introductionmentioning

confidence: 99%