Multicompartmental analysis of late contrast enhancement in areas of myocardial infarction supplied by chronically occluded coronary arteries

Abstract

Purpose: To analyze the relationship between late contrast enhancement (LCE) and the interstitial distribution volume (V In ) of gadolinium (Gd) tracers in the myocardial infarction (MI) areas supplied by chronically occluded arteries from patients. In animal experimental models, LCE has already been shown to correspond to an enhanced V In of Gd tracers and thus, to a decrease in the amount of intact cells. Materials and Methods:A multicompartmental analysis was applied to serial MRI images encompassing both infarct and remote areas and recorded with a conventional two-dimensional (2D) segmented inversion-recovery gradient-echo (IR-GRE) sequence during a 15-minute period following Gd-diethylenetriamine pentaacetic acid (Gd-DTPA) injection in 12 patients with Q-wave MI supplied by chronically occluded coronary arteries.Results: V In from infarct tissue was: 1) higher than V In from remote areas (in % of myocardial volume: 74 Ϯ 16% vs. 20 Ϯ 7%, P Ͻ 0.001); and 2) correlated with the quantification of LCE between infarct and noninfarct areas at the 15th minute (R 2 ϭ 0.63, P ϭ 0.002). However, the difference in V In between infarct and remote myocardium was a much better correlate of this quantified LCE (R 2 ϭ 0.85, P Ͻ 0.001). Conclusion:Detection of LCE in the MI territories supplied by chronically occluded arteries relates to the difference in the V In of tracers between the infarct and the noninfarct areas.

Comprehensive MRI analysis of early cardiac and vascular remodeling in middle-aged patients with abdominal obesity

“…Abdominal VAT was determined on an axial abdominal slice positioned at the level of L3-L4 [27][28][29]. This slice was recorded during breath-hold with a fast-spin-echo sequence and the following parameters: 10 mm slice thickness, 62 kHz bandwidth, 12 ms echo time and 7 echo train, 480 ms repetition time, 200 ms inversion time, field-of-view of 44-48 cm, 256 Â 190 matrix, and with water saturation in order that images contain only fat signal [30].…”

Features of Cardiac Remodeling, Associated With Blood Pressure and Fibrosis Biomarkers, Are Frequent in Subjects With Abdominal Obesity

“…A steady-state free precession pulse sequence was used to assess LV function in contiguous short-axis planes, as previously described in detail elsewhere. 12 LV end-diastolic volume, LV end-systolic volume, LV stroke volume, LV ejection fraction (EF), and LV mass were determined on the contiguous short-axis slices using dedicated software (MASS, Medis, The Netherlands). LV mass was determined at end diastole, and papillary muscles and trabeculations were excluded for LV mass and LV volume measurements.…”

“…LV mass was determined at end diastole, and papillary muscles and trabeculations were excluded for LV mass and LV volume measurements. 12 Different scales were used to normalize LV mass: height 1.7 , 13 height 2.7 , 14 and fat-free mass. 15 Cardiac remodeling index (CRI), indicating concentric LV remodeling, is represented by the ratio of LV mass/LV end-diastolic volume.…”