Multicomponent Domino Synthesis and Antibacterial Activity of Neomycin–Sugar Conjugates

Sganappa, Aurora; Bellucci, Maria Cristina; Nizet, Victor; Tor, Yitzhak; Volonterio, Alessandro

doi:10.1055/s-0035-1562727

Cited by 9 publications

(1 citation statement)

References 32 publications

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“…This strategy allows for the adjustment of the release sequence and rate of drugs, offering new possibilities for wound healing. Neomycin (NEO) is a polyaminoglycoside antibiotic noted for its excellent water solubility and potent antibacterial activity against both Gram-positive and Gramnegative bacteria [49]. In a study led by Xiao, Jin and Seidi, a pH-responsive self-healing polyvinyl alcohol (PVA)-borax hydrogel was prepared with the addition of NEO, dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA), and cellulose nanofibers (CNF) (Figure 4A,B) [25].…”

Section: Strategies For Drug-loaded Dynamic Hydrogelsmentioning

confidence: 99%

Dynamic Hydrogels against Infections: From Design to Applications

Zhang,

Zhu

2024

Gels

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Human defense against infection remains a global topic. In addition to developing novel anti-infection drugs, therapeutic drug delivery strategies are also crucial to achieving a higher efficacy and lower toxicity of these drugs for treatment. The application of hydrogels has been proven to be an effective localized drug delivery approach to treating infections without generating significant systemic adverse effects. The recent emerging dynamic hydrogels further show power as injectable formulations, giving new tools for clinical treatments. In this review, we delve into the potential applications of dynamic hydrogels in antibacterial and antiviral treatments and elaborate on their molecular designs and practical implementations. By outlining the chemical designs underlying these hydrogels, we discuss how the choice of dynamic chemical bonds affects their stimulus responsiveness, self-healing capabilities, and mechanical properties. Afterwards, we focus on how to endow dynamic hydrogels with anti-infection properties. By comparing different drug-loading methods, we highlight the advantages of dynamic chemical bonds in achieving sustained and controlled drug release. Moreover, we also include the design principles and uses of hydrogels that possess inherent anti-infective properties. Furthermore, we explore the design principles and applications of hydrogels with inherent anti-infective properties. Finally, we briefly summarize the current challenges faced by dynamic hydrogels and present a forward-looking vision for their future development. Through this review, we expect to draw more attention to these therapeutic strategies among scientists working with chemistry, materials, as well as pharmaceutics.

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Section: Strategies For Drug-loaded Dynamic Hydrogelsmentioning

confidence: 99%

Dynamic Hydrogels against Infections: From Design to Applications

Zhang,

Zhu

2024

Gels

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Aminoglycoside Conjugation for RNA Targeting: Antimicrobials and Beyond

Aradi

Giorgio

Duca

2020

Chemistry A European J

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Natural aminoglycosides are therapeutically useful antibiotics and very efficient RNA ligands. They are oligosaccharides that contain several ammonium groups able to interfere with the translation process in prokaryotesu pon binding to bacterial ribosomal RNA (rRNA), and thus, impairing protein synthesis. Even if aminoglycosides are commonly used in therapy,t hese RNA bindersl ack selectivity and are able to bind to aw ide number of RNA sequences/structures. This is one of the reasons for their toxicitya nd limited applications in therapy.A tt he same time, the ability of aminoglycosides to bind to various RNAs renders them ag reat source of inspirationf or the synthesis of new bindersw ith improved affinity and specificity toward several therapeutically relevant RNA targets. Thus, an umber of studies have been performed on these complex and highly functionalized compounds, leading to the development of various synthetic methodologies toward the synthesis of conjugated aminoglycosides. The aim of this review is to highlight recent progress in the field of aminoglycoside conjugation,p aying particulara ttention to modificationsp erformed toward the improvement of affinity and especiallyt ot he selectivity of the resulting compounds. This will help readers to understand how to introduce ad esired chemical modification for future developments of RNA ligandsa sa ntibiotics, antiviral, and anticancer compounds.

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Unleashing the Power of Domino Reactions on Carbohydrates: State of the Art

Antonini,

Petrosilli,

Giussani

et al. 2024

Eur J Org Chem

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The intricate nature of carbohydrate structures has prompted the scientific community to seek efficient protocols for their manipulation. Lengthy synthetic pathways, often necessary to achieve complex sugar structures, pose challenges not only in terms of time and cost but also regarding environmental sustainability. Consequently, domino transformations serve as valuable tools in streamlining drug discovery processes. Sequential procedures involving fewer steps and minimal isolation/purification steps are particularly appealing to organic chemists in the field of carbohydrate chemistry. This review highlights several examples of domino transformations applied to carbohydrates, aiming to summarize their chemical potential in delivering sugar‐based compounds with significant applications in the generation of new chemical scaffolds for drug discovery and chemical biology.

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Multicomponent Domino Synthesis and Antibacterial Activity of Neomycin–Sugar Conjugates

Cited by 9 publications

References 32 publications

Dynamic Hydrogels against Infections: From Design to Applications

Dynamic Hydrogels against Infections: From Design to Applications

Aminoglycoside Conjugation for RNA Targeting: Antimicrobials and Beyond

Unleashing the Power of Domino Reactions on Carbohydrates: State of the Art

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