Multicomponent one-pot solvent-free synthesis of functionalized unsymmetrical dihydro-1H-indeno[1,2-b]pyridines

Application of a biological‐based nanomagnetic catalyst in the synthesis of bis‐pyrazols and pyrano[3,2‐c]pyrazoles

“…The construction of pharmaceutically and medicinally active heterocyclic compounds, using one‐pot multicomponent strategies, has attracted much attention due to excellent merits such as enhancement of atom‐ and step‐economy and improvement of efficiency for the synthesis of complex scaffolds. Also, this technique offers meaningful benefits over conventional linear‐type synthesis protocols such as productivity, ease of execution and high yields …”

Catalyst-free multicomponent synthesis of novel adamantyl-containing tetrahydropyrimidine carboxylates

“…MCRs are advantageous due to high atom economy, simple operational procedures, and convergent characters [23]. These reactions have also been employed for the construction of C-N bonds and synthesis of different nitrogen containing heterocycles [20,24].…”

Tribromo melamine-catalyzed one-pot synthesis of a series of 4-aryl-4,5-dihydro-1H-indeno[1,2-b]pyridine derivatives

“…According to the literature, several synthetic methods have been developed for the construction of these types of fused heterocycles involving the condensation of aldehydes, 1,3-indandione or 1-indenone and aromatic ketones in the presence of ammonium acetate under microwave irradiation [12] and a novel three-component [5+1] heterocyclization leading to the synthesis of 2-azafluorenone and its polyfunctionalisations [13]. Several indeno [1,2-b]pyridine derivatives are synthesized by grinding [14] using 2,2,2-trifluoroethanol as the solvent [15], using L-proline (15 mol%) as the catalyst [16], by the Pummerer reaction of imidosulfoxides [17], using ceric ammonium nitrate as the catalyst [18] and a Pd(0)catalyzed cross-coupling reaction [19]. 5-Oxo-1H-4,5dihy-droindeno [1,2-b]pyridines have been synthesized by the condensation of 2-arylideneindane-1,3-diones with β-aminocrotonates in refluxing acetic acid [20].…”