Multicomponent phosphate invert glasses with improved processing

Brauer, Delia S.; Wilson, Rory M.; Kasuga, Toshihiro

doi:10.1016/j.jnoncrysol.2012.04.027

Cited by 17 publications

(11 citation statements)

References 32 publications

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“…[78b] Themixed-alkali effect is also known to improve the processing of glasses, [57] and it has been shown to improve the processing of bioactive glasses through lowering the glass transition temperature, increasing the crystallization temperature,a nd thereby widening the processing window. [142] Another approach for improving glass processing is the incorporation of intermediate ions such as magnesium, [44,99,128] which because of their larger field strength compared to modifiers [41a] effectively widen the processing window (Figure 15 b). [142] Another approach for improving glass processing is the incorporation of intermediate ions such as magnesium, [44,99,128] which because of their larger field strength compared to modifiers [41a] effectively widen the processing window (Figure 15 b).…”

Section: Methodsmentioning

confidence: 99%

Bioactive Glasses—Structure and Properties

2015

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Bioactive glasses were the first synthetic materials to show bonding to bone, and they are successfully used for bone regeneration. They can degrade in the body at a rate matching that of bone formation, and through a combination of apatite crystallization on their surface and ion release they stimulate bone cell proliferation, which results in the formation of new bone. Despite their excellent properties and although they have been in clinical use for nearly thirty years, their current range of clinical applications is still small. Latest research focuses on developing new compositions to address clinical needs, including glasses for treating osteoporosis, with antibacterial properties, or for the sintering of scaffolds with improved mechanical stability. This Review discusses how the glass structure controls the properties, and shows how a structure-based design may pave the way towards new bioactive glass implants for bone regeneration.

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Section: Methodsmentioning

confidence: 99%

Bioactive Glasses—Structure and Properties

2015

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“…This could be explained by the effect of increasing the crystallisation barrier, thus increasing the energy barrier for the rearrangement of atoms in order to form a critical size defect i.e. the entropy of mixing increases [36,53]. [60,61].…”

Section: Glass Characterisationmentioning

confidence: 99%

“…The glasses investigated had a fixed P 2 O 5 content at 40 mol% which can be considered to be on the verge of an invert phosphate glass formulation. Invert glasses are defined as containing <40 mol% of P 2 O 5 , where they predominantly consist of pyro-and orthophosphates, thus forming a highly depolymerised network with properties governed by the modifier ions [35,36].…”

Section: Introductionmentioning

confidence: 99%

Structural and physico-chemical analysis of calcium/strontium substituted, near-invert phosphate based glasses for biomedical applications

Patel¹,

Moss²,

Hossain³

et al. 2017

Acta Biomaterialia

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Neutron diffraction, 23 Na and 31 P NMR and FTIR spectroscopy have been used to investigate the structural effects of substituting CaO with SrO in a 40P 2 O 5 ·(16-x)CaO·20Na 2 O·24MgO·xSrO glass, where x is 0, 4, 8, 12 and 16 mol%. The 31 P solid-state NMR results showed similar amounts of Q 1 and Q 2 units for all of the multicomponent glasses investigated, showing that the substitution of Sr for Ca has no effect on the phosphate network. The M-O coordinations (M= Mg, Ca, Sr, Na) were determined for binary alkali and alkaline earth metaphosphates using neutron diffraction and broad asymmetric distributions of bond length were observed, with coordination numbers that were smaller and bond lengths that were shorter than in corresponding crystals. The Mg-O coordination number was determined most reliably as 5.0(2). The neutron diffraction results for the multicomponent glasses are consistent with a structural model in which the coordination of Ca, Sr and Na is the same as in the binary metaphosphate glass, whereas there is a definite shift of Mg-O bonds to longer distance. There is also a small but consistent increase in the Mg-O coordination number and the width of the distribution of Mg-O bond lengths, as Sr substitutes for Ca. Functional properties, including glass transition temperatures, thermal processing windows, dissolution rates and ion release profiles were also investigated. Dissolution studies showed a decrease in dissolution rate with initial addition of 4 mol% SrO, but further addition of SrO showed little change. The ion release profiles followed a similar trend to the dissolution rates observed. The limited changes in structure and dissolution rates observed for substitution of Ca with Sr in these fixed 40 mol% P 2 O 5 glasses were attributed to their similarities in terms of ionic size and charge.

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“…As such, modifications to the glass composition have been made to include bioactive inorganic ions such as Sr 2+ , Zn 2+ , Cu 2+ , Mg 2+ and B + ; see recent reviews on the subject by Lakhar et al and Habibovic and Barralet . Similarly, phosphate‐based glasses and invert glasses based on the simpler CaO‐Na 2 O‐P 2 O 5 system have received much attention for bone tissue engineering and dental applications due to their chemical similarity to the inorganic component of hard tissues and high solubility, which may be tuned by varying the composition of the melt . Previously, stability and crystallization inhibition has been enhanced in phosphate invert glasses by addition of intermediate oxides (TiO 2 , MgO, and ZnO) for example .…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8][9] Previously, stability and crystallization inhibition has been enhanced in phosphate invert glasses by addition of intermediate oxides (TiO 2 , MgO, and ZnO) for example. 9 Phosphate glasses have a much higher dissolution rate (in vivo residence times are generally days to weeks compared to 1-2 years for silicate bioactive glasses) and have therefore found use in a wide variety of biomedical applications such as the controlled release of ions, drugs and antibiotics, as well as both hard and soft tissue engineering scaffolds. 10,11 Here we investigate the potential of a hitherto unstudied class of soluble glasses for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

A new class of bioactive glasses: Calcium–magnesium sulfophosphates

Bassett

Mészáros

Orzol

et al. 2013

J Biomedical Materials Res

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Dental caries is an infectious microbiologic disease that results in destruction of calcified tissues. The routine drill and fill technique eliminates bacteria only at the site of restoration and recolonization can occur in remaining part of oral cavity. Present day treatment aims on conservation of tooth structure by identifying decalcification in earlier stages followed by treatment with remineralization. This paper discusses on various remineralization treatment options available and their mode of action.

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Multicomponent phosphate invert glasses with improved processing

Cited by 17 publications

References 32 publications

Bioactive Glasses—Structure and Properties

Bioactive Glasses—Structure and Properties

Structural and physico-chemical analysis of calcium/strontium substituted, near-invert phosphate based glasses for biomedical applications

A new class of bioactive glasses: Calcium–magnesium sulfophosphates

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