Multicomponent Reactions: Microwave-assisted Efficient Synthesis of Dihydropyrimidinones (thiones) and Quinazolinones under Green Chemistry Protocol as Probes for Antimicrobial Activities

Bhuiyan, Mosharef Hossain; Nessa, H.; Mahmud, Md. Mayez

doi:10.3329/jsr.v4i1.8688

Cited by 9 publications

(7 citation statements)

References 39 publications

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“…The result of activity of the synthesized compounds is shown in table 3 respectively. Based upon the value of ZOI in mm, compounds are classi ed as, signi cantly active (ZOI 15), moderately active (ZOI 13 to 14), poor active (ZOI 10 to12) and least active (ZOI less than The investigation of antibacterial screening shows that compound 3b exhibited highest activity against E.coli, have maximum zone of inhibition against S. aureus respectively [20]. Overall compound 3a 3e had good activity against both gram negative and gram positive bacteria.…”

Section: Anti-in Ammatory Activitymentioning

confidence: 99%

Green synthesis of pyrazolines as an anti-inflammatory, antimicrobial and antioxidant agents

Pawar¹,

Bhosale²,

Dhake³

et al. 2023

Preprint

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Green methods such as microwave technique and grinding technique has been found superior over the conventional method in view of reaction time and energy requirement. Comp research (2a-i), (3a-i) have been characterized by 1H NMR, 13C NMR, IR and mass spectral analyses. They were screened for their in vitro anti-inflammatory, antimicrobial and in vitro antioxidant activities. Antimicrobial activity was performed by Agar plate method and comp. 2d & 2e a active against gram negative bacteria E. coli and S. aureus, the comp. 3c and 3g show antioxidant activity as (IC50 = 48.13 and 46.03µg/ml), Comp’ 3c shows respectively anti-inflammatory activity at (EC50 = 11.00 ± 1.26 µg/mL). Comp. ,3c ,3d and 3e showed good anti-inflammatory activity at concentration (EC50 = 11.70 ± 0.98 µg/mL) & 11.70 ± 0.98 µg/mL respectively.

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Section: Anti-in Ammatory Activitymentioning

confidence: 99%

Green synthesis of pyrazolines as an anti-inflammatory, antimicrobial and antioxidant agents

Pawar¹,

Bhosale²,

Dhake³

et al. 2023

Preprint

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“…In continuation to earlier studies directed at the development of practical and efficient chemical processes (Bhuiyan et al, 2012;Basu et al, 2003), a sustainable Knoevenagel condensation protocol was reported using microwave irradiation (MWI) and ammonium acetate (NH 4 OAc) catalysis under solventfree conditions for the preparation of a-cyanoacrylates. The obtained compounds were screened for their antimicrobial activity.…”

Section: Spectral Data Ethyl 2-cyano-3-(2-methylphenyl)acrylate (1)mentioning

confidence: 99%

Microwave Assisted Knoevenagel Condensation: Synthesis and Antimicrobial Activities of Some a-Cyanoacrylates

Bhuiyan

Rahman²,

Alam³

et al. 2013

Pak. j. sci. ind. res. Ser. A: phys. sci.

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“…These flavones 8-10 were although synthesized previously via conventional methods which took unnecessary longer reaction time with moderate yields [21,22]. These observations, along with our continuous efforts towards the synthesis of medicinally important biomolecules [23,24], led us to apply and validate this combinatorial solvent-free MWI approach for the synthesis of flavones 8-10 and their precursor chalcones 5-7. Also, their PASS predication, in vitro antimicrobial efficacy, and ADMET properties are discussed herein.…”

Section: Introductionmentioning

confidence: 97%

Microwave Assisted Efficient Synthesis of Some Flavones for Antimicrobial and ADMET Studies

2020

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Microwave (MW) assisted synthetic technique was applied for the preparation of chalcone derivatives 5-7 employing Claisen-Schmidt condensation between 2-hydroxyacetophenone and aromatic aldehydes. These chalcones were further subjected to oxidative cyclization via MW irradiation and furnished the related flavones 8-10 which were characterized by FT-IR, 1H and 13CNMR spectra. The use of these MW assisted reactions provided higher productivity (92-98%) in shorter reaction time (2-6 min) with eco-friendly mild reaction conditions and hence found to be a convenient method as compared to conventional synthesis. These chalcones 5-7, and flavones 8-10 were screened for in vitro antimicrobial activities against five bacterial and three fungal pathogens. The study indicated that they were more active against fungal pathogens than that of bacterial organisms and comparable to the standard antifungal antibiotic nystatin. Interestingly, the prediction of activity spectra for substances (PASS) was also found in agreement with the in vitro results. Some of the compounds were found to have good ADMET properties.

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Multicomponent Reactions: Microwave-assisted Efficient Synthesis of Dihydropyrimidinones (thiones) and Quinazolinones under Green Chemistry Protocol as Probes for Antimicrobial Activities

Cited by 9 publications

References 39 publications

Green synthesis of pyrazolines as an anti-inflammatory, antimicrobial and antioxidant agents

Green synthesis of pyrazolines as an anti-inflammatory, antimicrobial and antioxidant agents

Microwave Assisted Knoevenagel Condensation: Synthesis and Antimicrobial Activities of Some a-Cyanoacrylates

Microwave Assisted Efficient Synthesis of Some Flavones for Antimicrobial and ADMET Studies

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